摘要
目的:观察二次TUR联合即刻膀胱灌注化疗药物治疗非肌层浸润性膀胱癌的安全性及疗效。方法:T1期非肌层浸润性膀胱癌患者120例分为2组:实验组58人,患者在第一次TUR术后24h内膀胱灌注化疗药物,4-6周行二次TURBt,以后按常规膀胱灌注化疗;对照组62人,TUR术后1周常规膀胱灌注化疗。观察两组肿瘤复发情况以及不良反应。结果:本组总复发率21.7%(26/120)。实验组1年内复发1例(1.7%),1-2年内复发4例(6.9%);对照组1年内复发8例(12.9%),1-2年内复发13例(21.0%),两组复发率比较差异有统计学意义(P<0.05)。实验组不良反应8例,对照组不良反应7例,比较差异无统计学意义(P>0.05)。结论:即刻膀胱灌注化疗及二次TUR可降低非肌层浸润性膀胱癌的复发率,不良反应并无增加。
Objective：To observe the effects of second transurethral resection combined with immediate reperfusion therapy in non muscle-invasive bladder cancer.Methods：All 120 cases with T1 bladder urothelial carcinoma patients were divided into 2 groups：58 in experimental group,to be treated with TUR within 24h after operation of bladder perfusion chemotherapy,4-6 weeks later treated with TURBt again;the control group 62 cases treated with TUR after 1 weeks of routine bladder perfusion chemotherapy.To observe the tumor recurrence and adverse reaction.Results：The total recurrence rate was 21.67%（26 /120）.In experimental group,recurrence within 1 year in 1 cases（1.7%）,1-2 years recurrence occurred in 4 cases（6.9%）,in control group recurrence within 1 year in 8 cases（12.9%）;1-2 years recurrence occurred in 13 cases（20.1%）,recurrence rates of the two groups had significant difference（P 0.05,P 0.05）.In experimental group 8 cases developed adverse reaction,control group 7 cases,no significant difference（P 0.05）.Conclusion：Second transurethral resection combined with immediate reperfusion therapy in non muscle-invasive bladder cancer can reduce the recurrence rate and side effects did not increase.
出处
《现代肿瘤医学》
CAS
2013年第8期1814-1816,共3页
Journal of Modern Oncology
基金
陕西省科技攻关计划(编号:2012K16-09-02)
关键词
非肌层浸润性膀胱尿路上皮癌
二次经尿道肿瘤电切
术后即刻膀胱灌注
non muscle-invasive bladder urothelium cancer
second transurethral resection
immediate postoperative instillation of chemotherapy
