摘要
目的分析6例肾集合管癌(collecting duct carcinoma,CDC)患者的临床病理特征,诊断及鉴别诊断。方法对6例CDC进行临床病理观察及免疫组化标记,并复习相关文献进行分析。结果病理检查显示肿瘤呈管状、乳头状结构,部分呈实性片状生长;肿瘤细胞表现为立方形及靴钉样,核分级FuhrmanⅢ级或Ⅳ级,肿瘤旁见异型增生的集合管上皮。免疫表型是肿瘤细胞表达广谱细胞角蛋白(CKpan)、PAX8,部分表达细胞角蛋白19(CK19)、细胞角蛋白7(CK7)、波形蛋白(Vimentin)(分别为4/6、3/6、3/6),不表达P63、细胞角蛋白20(CK20)、CD117、P504s。结论 CDC是一种少见的恶性度高的肾上皮性肿瘤,易误诊,免疫组化有助于该病的诊断及鉴别诊断。
Objective To study the clinicopathological features of collecting duct carcinoma（CDC） and the key points of its diagnosis and differential diagnosis, Methods The clinicopathological and immunohistochemical staining in six cases of CDC were presented with the review of relevant literature. Results Histologically,the tumor showed prominent tubular and tubular-papillary structures with desmoplastic stromal reaction. Simultaneously, the tubular epithelial atypical hyperplasia was observed in the adjacent renal medullary （Fuhrman nuclear grade Ⅲ or Ⅱ ）. Immunohistochemistry study showed that the tumor cells were positive for CKpan,PAX8 ,CK19（4/6）,CK7（3/6） and vimentin（3/6） ,negative for P63,PS04s,CD117,CK20. Conelusion CDC of kidney is a rare,high grade tumor and it is easily misdiagnosed. Immunohistochemistry plays an important role in its diagnosis and differential diagnosis.
出处
《临床荟萃》
CAS
2013年第7期735-737,F0002,共4页
Clinical Focus
关键词
肾肿瘤
肾小管
集合
病理学
临床
kidney neoplasms
kidney tubules, collecting
pathology, clinical
