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环氧化酶-2与肝纤维化的关系研究 被引量：3

Advances in the relationship of the cyclooxygenase-2 and liver fibrosis
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摘要 环氧化酶-2抑制剂抗肝纤维化形成的具体分子机制存在广泛争议。目前研究认为抑制环氧化酶-2对化学损伤性肝纤维化模型有治疗作用,却对免疫性肝纤维化模型起加重作用。该文综述了环氧化酶-2对肝纤维化的影响,旨在为不同病因导致肝纤维化的有效治疗提供新的途径或靶点。 The specific molecular mechanism of cyclooxygenase-2（cox-2） inhibitor in the generation of hepatic fibrosis is hot at home and abroad,in which there is widespread controversy.Now it’s considered the cyclooxygenase-2 inhibitor agent has a treatment in chemical liver fibrosis,while it aggravates immune liver fibrosis.This paper reviews the effects of cyclooxygenase-2 on hepatic fibrosis to provide a new way or target for liver fibrosis.
作者 陈昕晟 陈真
机构地区 中国药科大学药学医学基础实验教学中心
出处 《安徽医药》 CAS 2013年第7期1081-1082,共2页 Anhui Medical and Pharmaceutical Journal
关键词 环氧化酶-2 炎症 肝纤维化 免疫 cyclooxygenase-2 inflammation hepatic fibrosis immunity
分类号 R575.2 [医药卫生—消化系统]
  • 相关文献

参考文献20

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二级参考文献110

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共引文献45

同被引文献53

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引证文献3

二级引证文献7

安徽医药
2013年 第7期

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