摘要
目的:研究足三里注射黄芪注射液对气虚自汗模型大鼠体温调节中枢的作用。方法:以烟熏+灌胃麻黄汤法复制大鼠气虚自汗模型。实验分为对照(灌胃,等容生理盐水)组、模型(灌胃,等容生理盐水)组、生理盐水穴位注射(注射,等容生理盐水)组、参麦注射液穴位注射(注射,0.3ml/kg)组与黄芪高、低剂量穴位注射(注射,0.8、0.4ml/kg)组。每天给药1次,连续10d。以ELISA法检测大鼠下丘脑环磷酸腺苷(cAMP)、前列腺素(PG)E2、β-内啡呔含量。结果:与对照组比较,模型组大鼠丘脑cAMP、PGE2、β-内啡肽含量显著增加(P<0.05);与模型组比较,黄芪高、低剂量穴位注射组大鼠丘脑cAMP、PGE2、β-内啡肽含量显著减少(P<0.05)。结论:足三里注射黄芪注射液对气虚自汗大鼠的体温调节中枢有一定调节作用。
OBJECTIVE： To investigate the effects of Huangqi injection at acupuncture point Zusanli on thermotaxic centers in spontaneous sweat rats induced by qi deficiency. METHODS： Spontaneous sweat of rats induced by qi deficiency model was estab- lished by sootiness and Ephedra decoction. Model rats were divided into control group （i.g. constant volume of normal saline）, model group （i.g. constant volume of normal saline）, acupoint injection of normal saline group （constant volume of normal sa- line）, acupoint injection of Shenmai injection （0.3 ml/kg）, acupoint injection of Huangqi injection high-dose and low-dose groups （0.8, 0.4 ml/kg）. They were given medicines on acupuncture point Zusanli once a day for consecutive 10 days. The contents of 3＇, 5＇-cAMP, PGEz, fl-endorphin in hypothalamus of rats were determined by EIlSA. RESULTS： Compared with control group, the contents of cAMP, PGE2, fl-endorphin in hypothalamus of rats decreased significantly in model group （P〈0.01） ; compared with model group, the contents of cAMP, PGE2 and fl endorphin in hypothalamus of rats decreased significantly in acupoint injection of Huangqi injection high-dose and low-dose groups（P〈0.01 or P〈0.05）. CONCLUSIONS： Huangqi injection at acupuncture point Zusanli has effect on thermotaxic centers in spontaneous sweat rats induced by qi deficiency.
出处
《中国药房》
CAS
CSCD
2013年第31期2896-2898,共3页
China Pharmacy
关键词
黄芪注射液
足三里
气虚自汗
大鼠
体温调节中枢
Huangqi injection
Zusanli
Spontaneous sweat induced by qi deficiency
Rat
Thermotaxic centers
