摘要
目的 观察老年 2型糖尿病患者血浆血小板 α-颗粒膜蛋白 (GMP- 1 4 0 )的变化。方法 采用放免法 ,检测 2 0例正常人和40例老年 2型糖尿病患者 (2 2例无微血管病变 ,1 8例有微血管病变 )血浆 GMP- 1 4 0的变化 ,同时观察了患者用己酮可可减治疗后上述指标的变化。结果 糖尿病患者 GMP- 1 4 0显著高于正常对照组 ,己酮可可碱治疗后 GMP- 1 4 0则明显下降 ,伴微血管病变者比无微血管病变者变化更明显 ,且 GMP- 1 4 0与血栓素 B2 (TXB2 )呈显著正相关。结论 血浆 GMP- 1 4 0是老年 2型糖尿病患者血小板活化的直接和特异指标 ,有助于糖尿病微血管病变的早期诊断和病情分析 ,且能作为抗血小板药物疗效的指标。
Objective To observe the changes of plasma platelet α granule membrane protein(GMP 140) in the elderly type 2 diabetic patients.Methods The plasma GMP 140 was measured by radioimmunoassy in 40 elderly cases with type 2 diabetes mellitus(18 cases with microangiopathy,22 without microangiopathy) and 20 controls.Changes of GMP 140 were observed after treatment with pentoxifylline.Results GMP 140 was significantly higher in the diabetic patients than the controls,whereas obviously lower after treatment with Pentoxifylline.The changes of the above indices were more apparent in patients with microangiopathy.There was significant positive correlation between plasma GMP 140 and thromboxane B 2(TxB 2).Conclusions The plasma GMP 140 is a direct and specific index of platelet activation in elderly type 2 diabetic patients and useful for the early diagnosis and analysis of diabetic microangiopathy.It's also an index of curative effect for anti platelet drug remedy.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2000年第6期343-345,共3页
Chinese Journal of Gerontology
关键词
糖尿病微血管病变
血浆
血小板Α-颗粒膜蛋白
Diabetic microangiopathy Plasma platelet α granule membrane protein Pentoxifylline
