摘要
目的 探讨bcl 2蛋白表达在子宫腺肌病发生中的病理生理作用及其临床意义。方法 应用免疫组织化学法 ,检测 16例正常子宫及 32例子宫腺肌病患者子宫组织中bcl 2基因蛋白的组织定位和表达强度 ,对比其差异。结果 增殖期 ,bcl 2在正常子宫内膜及子宫腺肌病患者子宫在位、异位子宫内膜腺体中的表达强度分别为 (2 .0± 0 .3)、(2 .5± 0 .1)和 (3.0± 0 .1)分 ( x±s x,下同 ) (P <0 .0 5 ) ,在间质中的表达强度分别为 (0 .4± 0 .1)、(1.1± 0 .2 )和 (1.0± 0 .2 )分 (P <0 .0 5 ) ;分泌期 ,bcl 2在正常子宫及子宫腺肌病患者在位、异位子宫内膜腺体中的表达强度分别为 (0 .9± 0 .2 )、(1.3± 0 .2 )和 (1.7± 0 .2 )分 (P <0 .0 5 ) ,在间质中的表达强度分别为 (1.1± 0 .2 )、(0 .9± 0 .2 )和 (1.0± 0 .2 )分 (P >0 .0 5 )。在平滑肌中表达强度无明显变化。结论 bcl 2基因在子宫腺肌病子宫内膜中过度表达所致的细胞凋亡减弱 。
Objective To investigate the expression of B cell lymphoma/leukemia 2 (Bcl 2) protein in adenomyosis and its clinical implication. Methods Endometrium specimens were obtained from 16 normal uterus and 32 with adenomyosis. bcl 2 expression in these paraffin embraced specimens was examined by immunohistochemical technique with specific monoclonal antibodies. Results bcl 2 expression in normal endometrium showed a significant cyclic variation. bcl 2 expression of glandular cells in both eutopic and ectopic endometrium of adenomyosis also showed a significant cyclic variation. bcl 2 expression in endometrium of adenomyosis was stronger than that in normal endometrium, and bcl 2 expression in ectopic endometrium was stronger than that in eutopic endometrium. Conclusion The decrease of cellular apoptosis resulted from the high bcl 2 expression may play an important role in the pathogenesis of adenomyosis.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2000年第9期533-535,I011,共4页
Chinese Journal of Obstetrics and Gynecology
