摘要
目的研究调肝理脾和胃中药对胃食管反流病(GERD)患者症状及食管运动功能的影响。方法选取具有典型胃食管反流症状的GERD患者32例,评估其胃食管反流症状,行高分辨率食管测压,给予调肝理脾和胃中药治疗,对比治疗前后胃食管反流症状和食管动力的改变情况。结果与治疗前相比,调肝理脾和胃中药可降低胃食管反流各单项症状及总症状积分;GERD患者LES静息压低下者的压力值提高(P<0.05),UES静息压、UES松弛时间、LES松弛率无明显改变(P>0.05);GERD患者食管中、远段压力及远段食管收缩积分增加(P<0.05),吞咽成功率,蠕动速度无明显改变(P>0.05)。结论调肝理脾和胃中药可有效改善GERD患者的胃食管反流症状,增加食管LES压力和部分改善体部运动功能,提高患者抗反流能力。
Objective To explore Tiaoganlipihewei prescription（TGLP） on the effects of symptoms and function of esophageal motility in patients with gastroesophageal reflux disease（GERD）.Methods Thirty-two cases of GERD with typical gastroesophageal reflux symptoms were selected,and the symptoms were evaluated,high-resolution esophageal manometry was applied.All patients were treated with TGLP,then the change condition of gastroesophageal reflux symptom and esophageal motility before and after the treatment was compared.Results Compared with before the treatment,TGLP decreased each individual symptom of gastroesophageal reflux and total symptom score;the pressure value was increased in GERD patients of low LES resting pressure（P 0.05）,there was insignificant difference in UES resting pressure,UES relaxation time and LES relaxation rate（P 0.05）;the pressure of locus medialis and inferior,and the contraction score of locus inferior were increased（P 0.05）,while there was insignificant difference in the success rate of swallow and the peristalsis speed（P 0.05）.Conclusion TGLP has a good effect on improving the gastroesophageal reflux symptoms in GERD patients,increasing esophagus LES pressure and partly improving the function of esophageal body motility,as well as the anti-esophageal reflux.
出处
《北京中医药》
2013年第6期421-423,共3页
Beijing Journal of Traditional Chinese Medicine
基金
北京市卫生系统高层次卫生技术人才经费支持项目(2011-2-13)
关键词
胃食管反流病
调肝理脾和胃方
高分辨食管测压
中医药疗法
gastroesophageal reflux disease
Tiaoganlipihewei prescription
high-resolution esophageal manometry
TCM therapy
