摘要
采用改良Franz扩散池法进行实验,以延胡索乙素为指标,HPLC测定样品的含量,考察止痛凝胶膏剂的体外释放和经皮渗透行为。经统计分析,24 h内延胡索乙素累积释药率和释药速率为81.9%,2.26μg.cm-2.h-1;24 h累积经皮渗透率和速率分别为12.53%,0.27μg.cm-2.h-1,48 h内累积经皮渗透率和速率为20.31%,0.22μg.cm-2.h-1,表明止痛凝胶膏剂具有较好的释放和透皮性能,透皮行为符合零级动力学过程。
To evaluate in vitro release and transdermal behaviors of Zhitong cataplasm,modified Franz diffusion cell method was applied to investigate in vitro transdermal absorption of Zhitong cataplasm and the content of tetrahydropalmatine was determined by HPLC.In 24 hours,accumulative release rate of tetrahydropalmatine was 81.9%,transmission rate was 2.26 μg·cm-2·h-1.In 48 hours,accumulative transdermal rate and transmission rate of tetrahydropalmatine were 20.31%,0.22 μg·cm-2·h-1.So Zhitong cataplasm had a good release and transdermal properties and transdermal actions were consistent with zero-order kinetics process.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第14期2306-2308,共3页
China Journal of Chinese Materia Medica
基金
国家“重大新药创制”科技重大专项(2009ZX09103-387)
