摘要
目的 :通过对突聋患者血中NO含量的检测 ,探讨突聋与NO的关系。方法 :采用比色法测定 2 6例(30耳 )突聋患者血中NO含量 ,并以 2 5例健康人做为正常对照。结果 :突聋患者血中NO含量低于正常对照组 ,尤其是听力为 40～ 5 9dBHL时与正常对照组比较差异有显著性 ,P <0 0 1。伴有头晕的 8例突聋病人血浆NO含量明显低于单纯突聋患者 ,P <0 0 1。结论 :血中NO含量降低 ,可能是突聋的发病原因之一 ,适量的NO可扩张血管 ,加快血流 ,增加耳蜗微循环的灌注量。NO和氧自由基也是突发性聋发生时神经损伤的重要致病因素。
Objective:To observe the content of plasma nitric oxide in sudden deafness in order to study its pathogenic mechanism. Methods:Plasma nitric oxide of 26 patients (30 ears) with sudden deafness were measured by colorimetry and 25 normal hearing subjects served as control. Results:Plasma nitrc oxide of sudden deafness group were obviously lower than that of the control group(P<0 01), especially when the hearing was 40～59 dBHL. Plasma nitric oxide of 8 cases sudden deafness with dizziness were obviously lower than sudden deafness(P<0 01). Conclusion:The result indicated that lower plasma concentration of NO may act as the pathogenic factors predisposing occurrence of sudden deafness. NO might be used to cure inner ear disorder by dilating vessels and increasing velocity. NO and oxygen free radical were important factors for nervous injury when sudden deafness occurs.
出处
《内蒙古医学院学报》
2000年第3期164-166,共3页
Acta Academiae Medicinae Neimongol
