摘要
背景 骨癌性疼痛（bone cancer pain,BCP）或癌性骨痛是原发性恶性骨肿瘤或者骨转移癌患者最主要的临床问题,约85％的骨恶性肿瘤患者出现疼痛,从而导致焦虑甚至抑郁,降低其终末期的生活质量.BCP目前临床上难以达到彻底的疼痛缓解.近些年来,随着BCP动物模型的建立和成熟,其病理生理机制正逐渐被人阐述. 目的 总结BCP涉及到的病理机制,希望对临床寻找基于病理机制的治疗提供新的思路. 内容 综合和总结近5年内的研究文章,阐述BCP涉及的病理机制. 趋向 BCP病理机制复杂,涉及到肿瘤-脊髓.大脑的结构性、生理性、药理性等以及细胞因子和通路等的改变,研究建立在机制研究基础上的治疗手段将会给患者带来福音.
Background Bone Cancer Pain （BCP） or Cancer-Induced Bone Pain is the most common symptom of bone tumors,affecting up to 85% of the patients with primary bone cancer or secondary metastases,causing a significant decrease in the quality of life of patients with more advanced stages of cancer with pain associated anxiety,depression and loss of functions.So far,BCP has proven to be a challenge to manage clinically.However,with the recent development of animal models demonstrating pathological mechanisms of BCP,researchers hope to gain insights into possible manage methods in the future.Objective osummarize the pathological mechanisms of BCP,which maight offer new ideas or directions for its management.Content This article will give a detailed summary of the pathological mechanisms related to BCP by reviewing research articles published in last 5 years.Trend The current trend in research has been focusing on the developing treatments based on the complicated pathological mechanisms of BCP,which mostly involves structural,physiological and pharmacological alterations.Unclear because traitements based on the pathological mechanisms might be beneficial in the management of BCP.
出处
《国际麻醉学与复苏杂志》
CAS
2013年第6期555-558,共4页
International Journal of Anesthesiology and Resuscitation
关键词
骨癌性疼痛
病理机制
感觉神经元
炎症因子
Bone cancer pain
Pathological mechanism
Sensory neuron
Inflammatory factor
