摘要
目的：探讨二甲双胍联合氨氯地平治疗肥胖型轻中度高血压的疗效。方法：将2009年3月~2012年2月期间我院收治的138例肥胖型轻中度高血压患者随机分为观察组（n=69）与对照组（n=69）,前者接受二甲双胍联合氨氯地平治疗,后者仅接受氨氯地平治疗,现对比分析两组患者的疗效。结果：①治疗前,两组患者舒张压（DBP）、收缩压（SBP）、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）相比差异无统计学意义（P〉0.05）。治疗后,观察组DBP、SBP、FPG、HbA1c、TG、TC、LDL-C显著低于对照组,HDL-C显著高于对照组（P〈0.05）。②观察组、对照组治疗有效率分别为92.7%、75.3%,两组相比差异有统计学意义（P〈0.05）。③观察组、对照组不良反应发生率分别为10.1%、7.2%,两组相比差异无统计学意义（P〉0.05）。结论：二甲双胍联合氨氯地平治疗肥胖型轻中度高血压具有疗效确切、不良反应可以耐受等优点,该方案值得临床应用与推广。
Yang Xiaoqin（Department of Internal Medicine,Fengtai,District Nanyuan Hospital of Beijing,Beijing 100065,China）
Objective：To explore the therapeutic efficacy of metformin combined with amlodipine in the treatment of obese patients with mild to moderate essential hypertension.Methods：138 cases of obese patients with mild to moderate essential hypertension admitted into our hospital from March 2009 to February 2012 were randomly divided into observation group（n=69） and control group（n=69）,and the former received metformin combined with amlodipine,while the latter was given amlodipine.Results： ①Before treatment,there were no significant differences in the diastolic blood pressure（DBP）,systolic blood pressure（SBP）,fasting blood glucose（FPG）,glycosylated hemoglobin（HbA1c）,triglyceride（TG）,total cholesterol（TC）,high density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterol（LDL-C） between the 2 groups（P0.05）.After treatment,the DBP,SBP,FPG,HbA1c,TG,TC and LDL-C in the observation group were significantly lower than those in the control group respectively（P0.05）,while the HDL-C was significantly higher than that in the control group（P0.05）.②The effective rates in the observation group and the control group were 92.7% and 75.3% respectively,and there was significant difference between the 2 groups（P0.05）.③The incidence rates of adverse reactions in the observation group and the control group were 10.1% and 7.2% respectively,and there was no significant difference between the 2 groups（P0.05）.Conclusion：The metformin combined with amlodipine in the treatment of obese patients with mild to moderate essential hypertension shows good therapeutic efficacy and tolerable adverse reactions,so this procedure is worthy of being applied and popularized.
出处
《中国医药导刊》
2013年第5期843-844,共2页
Chinese Journal of Medicinal Guide
关键词
二甲双胍
氨氯地平
肥胖型轻中度高血压
糖脂代谢
Metformin
Amlodipine
Obese patients with mild to moderate essential hypertension
Glucose and lipid metabolism
