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肥厚型心肌病左心室舒张功能障碍研究进展 被引量：11

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摘要 左心室舒张功能障碍是肥厚型心肌病(HCM)患者最常见的病理生理学改变,是引起心力衰竭(心衰)症状、影响患者预后的重要因素。大量研究发现致病基因突变所致肌小节蛋白结构异常、心肌纤维化及能量代谢障碍都参与了HCM左心室舒张功能障碍的发生、发展。超声心动图是评价舒张功能障碍最常用的诊断工具。随着大量新的超声技术的应用,大大提高了对HCM舒张功能诊断的准确性。目前尚无针对舒张功能的特异性治疗手段,但大量临床证据提示经皮室间隔心肌消融术在解除左心室流出道梗阻的同时可以显著改善患者舒张功能。
作者 陈石 乔树宾
机构地区 北京协和医学院中国医学科学院阜外心血管病医院心血管疾病国家重点实验室
出处 《中国循环杂志》 CSCD 北大核心 2013年第4期316-318,共3页 Chinese Circulation Journal
关键词 肥厚型心肌病 舒张功能障碍 心力衰竭 心脏彩色超声心动图
分类号 R54 [医药卫生—心血管疾病]
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参考文献20

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二级参考文献12

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中国循环杂志
2013年 第4期

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