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血清半乳糖凝集素-3水平与肝衰竭预后相关性 被引量:3

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摘要 目的研究血清半乳糖凝集素-3(Galectin-3)水平和肝衰竭患者预后的关系。方法 2010年1月至2011年12月期间住院的中晚期肝衰竭患者59例,给予内科综合治疗并随访6个月,所有患者抽取外周血测Galectin-3水平;选取同时期的慢性乙型肝炎患者30例和健康对照者30例作为对照。结果健康对照组(n=30)血清Galectin-3水平为(0.0423±0.0208)ng/mL;慢性乙型肝炎组(n=30)为(0.1642±0.0556)ng/mL,较健康对照组增高,差异有统计学意义(F=2.701,P<0.01);肝衰竭组(n=59)为(0.4825±0.2436)ng/mL,与慢性乙型肝炎组(F=8.121,P<0.01)及健康对照组(F=11.231,P<0.01)比较,差异均有统计学意义。肝衰竭死亡组(n=25)血清Galectin-3水平为(0.2004±0.1086)ng/mL,低于存活组(n=34)的(0.5937±0.2273)ng/mL,差异有统计学意义(t=6.710,P<0.001)。结论 Galectin-3水平和肝衰竭患者的预后正相关,Galectin-3上调可能是肝组织严重损伤时机体的一种保护因素。
出处 《肝脏》 2013年第7期461-462,共2页 Chinese Hepatology
基金 南京市医学科技发展重点项目(201108014) 南京市医学科技发展项目(YKK12116)
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  • 1林贤丰,李凌菲,俞燮琰,肖冬冬,吴圣杰,陈黎黎,宋梅,刘文悦,施可庆,陈永平,郑明华.MELD相关评分体系对乙型肝炎相关慢加急性肝衰竭患者预后的预测价值[J].中华临床医师杂志(电子版),2012,6(19):5853-5857. 被引量:11
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