摘要
目的:初步探索血管源性轻度认知障碍的证候要素,为辨证规范的建立提供依据。方法:多中心协作收集血管源性轻度认知障碍病例803例。采用因子分析寻找该疾病的常见证候要素,并统计证候要素分布特点。结果:最终得到6种证候要素,其中气虚比例为25.90%,其后依次为血瘀(18.31%)、痰(16.94%)、阴虚(14.32%)、阳虚(13.57%)、火(10.96%)。涉及的主要脏腑为肾、肝,次要脏腑为心、脾。蒙特利尔认知量表(MoCA)得分高的患者气虚、痰、血瘀较为常见;MoCA得分低的患者气虚、阳虚、血瘀较为常见。MoCA认知功能亚项受损数目与气虚得分呈正相关,相关系数为0.135(P<0.01)。结论:血管源性轻度认知障碍的证候要素以虚为本,以血瘀、痰实为标,并随疾病进展而演变。
Objective： To explore the syndrome factors distribution for vascular mild cognitive impairment, in order to provide the evidence for the standardization of syndrome differentation. Methods： 803 cases of vascular mild cognitive impairment were selected from multi-centers. Factor analysis was used to find out the common syndrome factors. Then, the distribution of syndrome factors was summary. Results： The distribution of the 6 syndrome factors were： patients with qi deficiency up to 25.90%, followed by blood stasis （18.31%）, phlegm （16.94%）, yin deficiency （14.32%）, yang deficiency （13.57%）, fire （10.96%）. The main involved organs were the kidney and liver, followed by the heart and spleen. Patients with higher MoCA score manifested commonly as qi deficiency, phlegm, blood stasis. Patients with lower MoCA score manifested commonly as qi deficiency, yang deficiency, blood stasis. There was positively correlation between the number of damaged cognitive function sub-items and qi deficiency score, and the correlation coefficient was 0.135 （P〈0.01）. Conclusion： The syndrome factors of take deficiency as root cause and blood stasis, phlegm camee as symptoms cause and evolved with the progress of the.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2013年第9期2596-2600,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
2008年中医药行业科研专项(No.200807011)
2010年中医药行业科研专项(No.201007002)
2010年度北京市社区中医药服务科技示范项目
北京市新医药学科群建设项目(No.XK100270569)
北京中医药大学创新团队(No.2011-CXTD-23)~~
关键词
血管源性轻度认知障碍
因子分析
证候要素
Vascular mild cognitive impairment
Factor analysis
Syndrome factors
