摘要
[目的]利用弥散张量成像探讨脑胶质瘤放疗后的早期变化。[方法]31例诊断明确的脑胶质瘤部分切除术后患者,在放疗前后1周内分别行MRI平扫＋增强＋DTI检查,分析肿瘤瘤体区及剂量相关区域的FA、ADC值变化。[结果]肿瘤瘤体区放疗后FA及ADC值均升高,放疗前后差异均有统计学意义（P〈0.05）。剂量〉60Gy时正常白质FA值放疗后升高,50~60Gy、30~40Gy、20~30Gy区域的正常白质放疗后FA值均下降,差异均无统计学意义（P〉0.05）;剂量〉60Gy、50~60Gy、40~50Gy、30~40Gy、20~30Gy区域的ADC值升高,但放疗前后的差异亦无统计学意义（P〉0.05）。[结论]放疗前、后肿瘤瘤体区FA、ADC值变化能较早提供肿瘤对放疗反应评估。
[ Purpose ] To evaluate the value of diffusion-tensor imaging （DTI） in the radiotherapy for gliomas. [Methods] Thirty-one patients with gliomas pathologically proved after partial surgi- cal resection underwent routine MRI contrast-enhanced scanning and DTI pre- and post-radio- therapy（pre-RT and post-RT）. The regions of interest （ROI）were placed on the central tumor re- gion and normal-appearing white matter（NAWM）. The FA and ADC values were calculated auto- matically from both pre-RT and post-RT image sequences. [Resultsl Compared to pre-RT,FA and ADC values increased post-RT in tumor region with significant differences （P〈0.05）. Com- pared to pre-RT about NAWM,FA values inclined for dose bins 〉60Gy,inclined for dose bins of 50-60Gy, 30-40Gy,20-30Gy groups post-RT. Neither had significant differences （P〉0.05）. For dose bins 〉60Gy,50~60Gy, 30~40Gy,20~30Gy groups,ADC values inclined post-RT,nei- ther had significant differences （P〉0.05）. [Conclusion ] DTI can early provide important infor- mation about effect of radiotherapy.
出处
《肿瘤学杂志》
CAS
2013年第8期628-631,共4页
Journal of Chinese Oncology
关键词
脑胶质瘤
弥散张量成像
放射治疗
brain gliomas
diffusion-tensor imaging
radiotherapy
