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肿瘤中STAT3、P-STAT3的表达及与EMT关系的研究进展

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摘要 上皮细胞间质化(Epithelial mesenchymal transition,EMT)是指具有极性的上皮细胞转化成具有活动能力的间质细胞的过程,在胚胎发生与器官发育、肿瘤形成和转移以及组织纤维化等生理病理过程中均有表现;STAT3是酪氨酸磷酸化激活的STAT家族成员之一,它的异常激活与细胞的恶性转化进程密切相关。研究表明,在肿瘤的发生发展机制中,STAT3可以通过影响EMT现象进而在肿瘤的发生、发展中起到极为关键的作用。本文综合目前的相关研究进展,就STAT3、P-STAT3及EMT在肿瘤侵袭转移中的作用及其分子机制作一综述。
作者 钟宝元 刘艳秀
机构地区 赣南医学院第一附属医院胃肠外科 赣州市人民医院
出处 《赣南医学院学报》 2013年第4期638-641,共4页 JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词 STAT3 P—STAT3 EMT 肿瘤
分类号 R392-33 [医药卫生—免疫学]
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参考文献28

  • 1Lee JH, Marshall JC, Steeg PS, et al. Altered gene andprotein expression by Nm23-H1 in metastasis suppression [J]. Mol Cell Biochem,2009,329( 1 -2) :141 - 148.
  • 2Allan AL, Vantyghem SA,Tuck AB, et al. Tumor dorman- cy and cancer stem ceils: implications for the biology and treatment of breast cancer metastasis [ J . Breast Dis, 2006, 26 : 87 - 98.
  • 3Townson JL, Chambers AF. Dormancy of solitary metastat- ic cells [ J 1. Cell Cycle ,2006,5 (16) : 1744 - 1750.
  • 4Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges [ J ]. Nat Med, 2006, 12 ( 8 ) : 895 - 904.
  • 5Horak CE, Lee JH, Marshall JC, et al. The role of metasta- sis suppressor genes in metastatic dormancy [ J ]. APMIS, 2008,116(7 -8) :586 -601.
  • 6Zhong Z, Wen Z, Darnell JE Jr. STAT3: a STAT family member activated by tyrosine phosphory -lation in re- sponse to epidermal growth factor and interleukin-6 [ J ]. Science, 1994,264(5155 ) :95 - 98.
  • 7Yu XT,Zhu SN, Xu ZD, et al. Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats[ J]. J Cancer Res Clin Oncol, 2007,133 (3) : 145 - 152.
  • 8Lee J, Kang WK, Park JO, et al. Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma [ J ]. AP- MIS,2009,117 (8):598 -606.
  • 9Kawada M, Seno H, Uenoyama Y, et al. Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer [ J ]. Cancer Research,2006,66 (6) : 2913 - 2917.
  • 10赵勇,王杉,叶颖江,周静,姜可伟,崔志荣.Stat3显性负性基因调控人结肠癌细胞增殖与凋亡的分子机制[J].中华普通外科杂志,2006,21(9):662-665. 被引量：5

二级参考文献15

  • 1殷涛,王春友,刘涛,赵刚,查运红.胰腺癌组织中Snail与E-钙黏素蛋白的表达及临床意义[J].中华医学杂志,2006,86(40):2821-2825. 被引量：14
  • 2殷涛,王春友,赵刚,刘涛,周峰,陶京.转化生长因子-β_1诱导的上皮向间叶转化对胰腺癌侵袭和转移的意义[J].华中科技大学学报（医学版）,2007,36(1):67-70. 被引量：5
  • 3Bromberg JF,Wrzeszczynska MH,Devan G,et al.Stat3 as an oncogene.Cell,1999,98:295-303.
  • 4Epling-Burnette PK,Liu JH,Catlett-Falcone R,et al.Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.J Clin Invest,2001,107:351-362.
  • 5Turkson J,Zhang S,Mora L,et al.A novel platinum compound inhibits constitutive stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells.J Bio Chem,2005,280:32979-32988.
  • 6Kusaba T,Nakayama T,Yamazumi,et al.Expression of p-Stat3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors.J Clin Pathol,2005,58:833-838.
  • 7Catlett-Falcone R,Landowski,Oshiro,et al.Constitutively activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells.Immunity,1999,10:105-115.
  • 8Fukada T,Ohtani T,Yoshida Y,et al.Stat3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition.EMBO J,1998,17:6670-6677.
  • 9Sinibaldi D,Wharton W,Turkson J,et al.Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts:role of activated STAT3 signaling.Oncogene,2000,19:5419-5427.
  • 10Garcia R,Bowman TL,Niu G,et al.Constitutive activation of Stat3 by the Src and JAK tyrosine kinase sparticipates in growth regulation of human breast carcinoma cells.Oncogene,2001,20:2499-2513.

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赣南医学院学报
2013年 第4期

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