摘要
目的 探讨中国人缺血性脑卒中与凝血因子 (F )基因 arg35 3g1n及 del(- 32 3) ins多态性的关系。方法 利用 PCR技术和分子杂交技术对北京地区 2 94例缺血性脑卒中患者进行 F 基因 arg35 3g1n及 del(- 32 3) ins多态性的检测和分析 ,并与 2 79例北京地区的非卒中对照进行比较。结果 缺血性脑卒中患者 F 基因 arg35 3g1n及 del(- 32 3) ins多态性的基因型频率和等位基因频率与对照组相比无明显差异。结论 F 基因arg35 3g1n及 del(- 32 3) ins多态性可能不是中国人群缺血性脑卒中发病的遗传学危险因素。
Objective To investigate whether FⅦ arg353gln and del(-323)ins polymorphisms are associated with ischemic stroke.Methods FⅦ arg353gln and del(-323)ins polymorphisms were determined by polymerase chain reaction (PCR) and molecular hybridization in 294 cases of ischemic stroke and 279 controls selected from Beijing population.Two groups were matched in sex,age and blood pressure.Results The prevalence rates of genotype frequency and allele frequency of FⅦ arg353gln and del(-323)ins polymorphisms are not significantly different between ischemic stroke cases and controls (P>0.05).Conclusion FⅦ arg353gln and del(-323)ins polymorphisms are not associated with ischemic stroke.
出处
《山西医药杂志》
CAS
2000年第5期385-387,共3页
Shanxi Medical Journal
