摘要
目的 :探讨血管内皮细胞生长因子在大肠癌中的表达规律。方法 :应用VEGF抗体 ,采用免疫组化S -P法 ,对 6 2例大肠癌组织和 6 2例正常大肠上皮进行染色。结果 :大肠癌组织中VEGF的表达明显高于正常对照组 (P <0 .0 5 ) ,伴有淋巴结转移或远处转移的大肠癌组织中VEGF的表达明显高于其相应无转移组 (分别为P <0 .0 5和P <0 .0 1) ,DukesC期大肠癌中VEGF的表达亦明显高于DukesA、B期大肠癌 (P <0 .0 5 )。结论 :大肠癌组织中有VEGF的高水平表达 ,VEGF与大肠癌的生长。
Objective To explore the expression rule of vascular endothelial growth factor (VEGF) in colorectal carcinoma.Methods The expression of VEGF in 62 colorectal carcinoma and 62 normal colorectal mucosa were measured with VEGF-antibody by immunohistochemistry S-P.Results The expression of VEGF in colorectal carcinoma was significantly higher than that in normal mucosa( P <0.05); the VEGF expression in carcinoma with lymph node metastasis and distant metastasis was higher than that in corresponding non- metastasis( P <0.05 and P <0.01); VEGF expression in Dukes C colorectal carcinoma also higher than that in Dukes A、B.Conclusion There was a high-level expression in colorectal carcinoma, VEGF positively correlated with the growth and metastasis of colorectal carcinoma.
出处
《郧阳医学院学报》
2000年第3期129-130,共2页
Journal of Yunyang Medical College
关键词
内皮生长因子
大肠肿瘤
腺癌
表达
endothelial growth factor
intestinal neoplasms
adenocarcinoma
