摘要
随着纳米技术的发展,越来越多的纳米产品开始进入人们的日常生活,纳米材料的毒性因此成为人们日渐关注的问题.近年来,纳米材料毒性的研究取得了很大进展,包括体内和体外实验研究纳米材料与生物大分子、细胞、器官和组织的相互作用以及其引起的毒性.纳米材料通过诱导氧化应激和炎症反应等机制产生一系列毒性效应.纳米材料本身的物理化学性质对其毒性有决定性的影响,这些性质包括尺寸、形状、表面电荷、化学组成、表面修饰、金属杂质、团聚与分散性、降解性能以及"蛋白冠"的形成.阐明物化性质对纳米材料毒性的影响,对于纳米材料的合理设计和安全应用具有重要的意义.本文对影响纳米材料毒性的关键因素进行了总结和分析,对近年来纳米材料毒性效应的研究进展进行了综述.
With the development of nanotechnology, more and more commercial nanoproducts enter our daily life. Therefore, the toxicity of nanomaterials becomes an increasing concern. Recently, great progress has been achieved in this field, which includes in vitro and in vivo experimental studies of the interactions between nanomaterials and biomacromolecules, cells, tissues and organs, and the toxicity they caused. Series of toxic effects of nanomaterials are caused by some mechanisms, such as the oxidative stress, inflammatory reaction, autophagy, and so on. These toxic effects are crucially affected by the intrinsic physicochemical properties of nanomaterials, which include size, shape, surface charge, surface modification, chemicai composition, metal impurities, agglomeration and dispersion, degradation, and the formation of ＂protein corona＂. Therefore, it is highly significant to illuminate these effects caused by different properties for designing nanomaterials rationally and applying them safely. In this review, we summarize and analyze the key factors which influence the toxicity of nanomaterials and the related research progress in recent ten years.
出处
《科学通报》
EI
CAS
CSCD
北大核心
2013年第24期2466-2478,共13页
Chinese Science Bulletin
关键词
纳米材料
纳米毒理学
物理化学性质
蛋白冠
氧化应激
炎症
nanomaterials, nanotoxicology, physicochemical properties, protein corona, oxidative stress, inflammation
