摘要
目的 探讨CYP1A1 2454A〉G多态性与结直肠癌易感性的关系。方法 通过检索PubMed、Embase和Web of Science databases数据库，对有关CYP1A1基因多态性与结直肠癌易感性关系的英文文献，用STATA 10.0软件进行Meta分析。结果 共纳入文献15篇，包括6768例患者和7973个对照，CYP1A1 2454A＞G与结直肠癌易感性显著相关（G比A：OR＝1.19，95 % CI＝1.03～1.37；GG比AA：OR＝1.40，95 % CI＝1.12～1.75；GG比AG＋AA：OR＝1.43，95 % CI＝1.15～1.78）。结论 CYP1A1 2454A＞G基因多态可能与结直肠癌易感性有关。
Objective To evaluate the association between CYP1A1 polymorphism and colorectal cancer risk. Methods PubMed, Embase and Web of Science databases were searched using the search terms as ＇Cytochrome P4501A1＇, ＇CYP1A1＇, ＇polymorphism＇ and ＇colorectal cancer＇. A meta-analysis was performed by STATA 10.0 software to assess the data included. Results By using 6768 cases and 7973 controls from 15 studies,significantly elevated colorectal cancer risks were associated with CYP1A1 2454A〉G in the following models （G vs A： pooled OR = 1.19, 95 % CI = 1.03-1.37; GG vs AA： OR = 1.40, 95 % CI = 1.12-1.75; GG vs AG＋AA： OR = 1.43, 95 % CI = 1.15-1.78）. Conclusion CYP1A1 2454A〉G may cause an increased risk of colorectal cancer.
出处
《肿瘤研究与临床》
CAS
2013年第8期535-538,共4页
Cancer Research and Clinic
基金
昆山市科技计划（KS1132）
中华国际医学交流基金会先声抗肿瘤治疗专项科研基金（CIMF-F-H001-109）
