摘要
目的：探讨人胆管癌细胞中nm23－H1的表达水平与胆管癌转移的关系。方法：应用S－P免疫组化法对52例人胆管癌细胞中nm23－H1的表达水平进行研究。结果：nm23－H1低表达者淋巴结转移率（60．0％）高于正常表达者（19．0％，P＜ 0．05），并且nm23－H1基因的表达水平和胆管癌组织学类型、分化程度存在明显相关（P＜ 0．05）。结论：nm23－H1的低表达在胆管癌的淋巴转移中起重要作用。
Objective To study the correlation of the expression of nm23－H1 with the biological behavior and lymph node metastasis of cholangiocarcinoma． Methods The nm23－H1 expression in 52 patients with cholangiocarcinoma were determined by using immunohistochemical method． Results The positive rate of nm23－H1 in 52 cases of cholangiocarcinoma was 63％． There were significant differences in level of nm23－H1 expression in different histopathological types and degrees of differentiation P＜ 0．05． nm23－H1 low－expression tumors were associated with a higher incidence of metastasis to lymph nodes in contrast with normal nm23－H1 expressionP＜ 0．05． Conclusion It is suggested that nm23－H1 low expression play a significant role in lymph node metastasis in cholangiocarcinoma．
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2000年第12期889-891,共3页
Chinese Journal of Clinical Oncology
基金
全军医药卫生科研基金
重庆市应用基础研究项目资助
