摘要
目的 :观察爆震后耳蜗毛细胞和螺旋神经节细胞的变化。 方法 :复制强脉冲噪声致聋豚鼠模型 ,以脑干听觉诱发电位测试仪测定听神经脑干反应 (ABR)阈值 ,通过耳蜗铺片计算机图像分析行毛细胞计数 ,耳蜗病理切片螺旋神经节细胞计数。结果 :正常对照组和噪声暴露后 2 1d的实验组耳蜗钩回、第 1和第 2回毛细胞总数分别为 3 5 99± 15 9.6个 ,6 0 2 2± 98.4个 ;二下螺旋神经节细胞计数分别为 (5 1± 4.72 )个 ,(2 7± 6 .94)个 ,以上均数各组间相差显著。结论 :爆震后不仅 ABR阈值升高 ,毛细胞数减少 。
Objective: To study quantitative changes of cochlear hair cells and spiral ganglion cells after blast exposure in guinea pigs. Methods: The number of hair cells was calculated using the surface specimen technique and computer image analysis technique after blast exposure. The number of spiral ganglion cells was calculated using pathologic technique and computer image analysis technique after blast exposure. Results: Quantitative observation was carried out 21 days after blast exposure. The number of total hair cells in uncus, the first and second gyre in normal control group and in blast group was 3 599±159.6 and 6 022±98.4 respectively, and the number of spiral ganglion cells in the 2 low parts of cochlear in normal control group and in blast group was 51± 4.72 and 27± 6.94 respectively, the difference in mean value between the groups being significant. Conclusion: Not only the hair cells reduce, but also the spiral ganglion cells are severely damaged after blast exposure. [
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2000年第12期1143-1145,共3页
Academic Journal of Second Military Medical University
关键词
爆震
耳蜗毛细胞
螺旋神经节细胞
聋
noise
cochlear hair cells
spiral ganglion cells
hearing loss
