摘要
目的:探讨0.5%消旋山莨菪碱滴眼液和2%盐酸卡替洛尔滴眼液治疗儿童近视的有效性。方法:患者双眼点用0.5%消旋山莨菪碱滴眼液和2%盐酸卡替洛尔滴眼液,早晚各一次。对用药前后的年近视发展度、眼轴、眼压和视力进行配对t检验,采用用药前后自身对照。定期观察近视发展情况。结果:年龄7～14岁(平均10.12±2.56岁),接受治疗时间1.0～2.5年。用药前后年近视发展度分别为(-1.05±0.53)D/年和(-0.56±0.55)D/年。用药后年近视发展度明显少于用药前(P<0.01)。用药前及用药后随诊矫正视力分别为4.83±0.12和4.94±0.23,用药后末次随诊矫正视力优于用药前(P<0.01)用药前后眼轴分别为(23.84±1.66)mm和(24.50±1.89)mm,用药后眼轴较用药前增长(P>0.05)。结论:点用山莨菪碱联合盐酸卡替洛尔滴眼液具有延缓近视发展的作用。
Objective： To evaluate the efficacy of 0.5%raceanisedamine and 2%carteolol hydrochloride eye drops for the treatment of childhood myopia.Methods：Both eyes were treated with0.5%raeeanisedamine and 2%carteolol hydrochloride eye drops twice daily tor more than a year. The patients were followed up every half year during the treatment period.A paired sample t-test was used to compare the yearly progression of myopia, axial length,intraocular pressure and visual acuity before and after treatment.Results ： 60 children completed the trial.The yearly progression of myopia before and after treatment was-1.05±0.53 diopters per year and -0.56± 0.55 diopters peryear.respeetively,and after treatment progression was signifieandy slower than before treatment （P 〈0.00）.The corrected visual aeuities before treatment and at the last visit were 4.83 ±0.12and 4.94±0.23.respectively,and the corrected visual acuity at the last visit was signifieanfly better than before treatment （P〈0.002）.The axial lengths before and after treatment were （ 23.84±1.66 ）mm and（ 24.50：1：1.89 ）mm.respectively, and axial length after treatment was significantly longer（ P〉0.05 ）Conclusion ： 0.5%raeeanisedamine eye drops and 2%carteolol hydrochloride eye drops were effective in slowing the progression of myopia.
出处
《北方药学》
2013年第10期18-19,共2页
Journal of North Pharmacy
