摘要
目的:探讨肾康注射液联合血液透析治疗慢性肾功能衰竭(CRF)患者的临床疗效。方法:将41例慢性肾衰终末期维持血透患者随机分成肾康注射液治疗组(简称治疗组)19例和单纯血透治疗对照组(简称对照组)22例,两组均进行标准的透析方法,在对症处理相同的条件下维持血透治疗。对照组每周3次血液透析治疗,治疗组在进行对症治疗的基础上,每周透析2次,每次透析完后给予肾康注射液。分别观察两组患者血肌酐(Scr)和血尿素氮(BUN)水平、透析充分性、营养状况、中医证候等方面的变化。结果:治疗组与对照组在肾功能、透析充分性、营养指标及电解质方面均无显著差异(P>0.05);治疗组中医证候疗效总有效率84.21%,对照组45.45%,治疗组优于对照组(P<0.05);两组肌肤甲错、肢体麻木、大便干结症状改善不明显,差异无统计学意义(P>0.05);倦怠乏力、气短懒言、食少纳呆、头晕、头痛、腰痛、自汗症状改善明显,差异有统计学意义(P<0.05),治疗组优于对照组。两组在治疗前后均进行了三大常规、心电图、肝功能、肾功能、电解质检查,无异常表现。治疗组患者在使用肾康注射液期间,未发现有明显不良反应,安全性较好。结论:肾康注射液联合血液透析治疗慢性肾功能衰竭,能够改善患者的临床症状,提高患者的生活质量。在达到充分透析的情况下,肾康注射液有可能减少每周的透析次数。
This study was aimed to explore the clinical efficacy of Shen-Kang Injection（SKI） combined with hemodialysis in the treatment of chronic renal failure（CRF） patients.A total of 41 end-stage CRF patients under the hemodialysis treatment were randomly divided into the SKI treatment group of 19 cases and a control group of 22 cases.Both groups were treated with standard dialysis and the hemodialysis was maintained in the same symp tomatic treatment conditions.Patients in the control group underwent three hemodialysis treatments in one week,while those in the treatment group were given hemodialysis twice a week based on the symptomatic treatment.And SKI was given after each time of hemodialysis in the treatment group.Indexes and changes in serum creatinine（Scr）,blood urea nitrogen（BUN） level,dialysis adequacy,nutrition status,traditional Chinese medicine（TCM） syndrome and other aspects of both groups were observed.The results showed that in the treatment group and control group,there were no significant differences in the renal function,dialysis adequacy,nutrition indicators and electrolyte（P〈0.05）.In the treatment group,the total efficiency of TCM syndrome was 84.21%.And the total efficiency of TCM syndrome in the control group was 45.45%.The treatment group was better than the control group（P〈0.05）.Symptoms such as scaly dry skin,numbness of the four limbs and dry stool were not obviously improved.And there was no statistical significance（P〈0.05）.Symptoms such as fatigue,shortness of breath,poor appetite,dizziness,headache,lower back pain and spontaneous sweating were improved significantly.And there was statistical significance（P〈0.05）.The treatment group was better than the control group.There were no abnormalities in the routine tests of blood,urine and stool,electrocardiogram,liver function,renal function and electrolyte.In the treatment group,there was no significant adverse reactions during patients received SKI.The SKI has good safety.It was concluded that SKI combined with hemodialysis in the treatment of CRF is able to improve the clinical symptoms of patients and improve the patients＇ quality of life.When patient received adequate dialysis,SKI may reduce the dialysis frequency per week.
出处
《世界科学技术-中医药现代化》
北大核心
2013年第4期746-752,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
成都中医药大学附属医院院重点基金项目(2011-D-YY-08):肾康注射液在血液透析中的协同作用研究
负责人:赵良斌
关键词
肾康注射液
肾功能衰竭
慢性
中西医结合治疗
血液透析
协同作用
临床观察
Shen-Kang Injection
renal failure
chronic / integrative medicine treatment
hemodialysis
synergistic effect
clinical observation
