摘要
目的研究生长抑素(SS)联合前列腺素E1(PGE1)治疗重症急性胰腺炎的临床疗效。方法对照组给予吸氧、禁食、胃肠减压、纠正水电解质紊乱、抑酸、抗感染及营养支持等基础治疗,同时加用SS治疗;观察组在上述治疗基础上再加用PGEl治疗,对比分析两组的临床疗效。结果观察组症状缓解时间、体征缓解时间、恢复进食时间和平均住院时间均明显短于对照组(P<0.05);观察组治疗后3、5、7 d血淀粉酶下降更明显,治疗后2、3、5、7 d血钙上升明显,与对照组比较差异有统计学意义(P<0.05)。观察组治愈率为30.0%,总有效率为95.0%;对照组治愈率为10.5%,总有效率为78.9%,两组比较差异均有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论 SS联合应用PGEl治疗重症急性胰腺炎的疗效明显优于单用SS治疗,值得临床推广应用。
Objective To study the clinical efficacy of somatostatin （SS）combined with prostaglandin E1 （PGE1） in the treatment of severe acute pancreatitis.Methods Patients in control group were given the basic treatment （such as oxygen,fasting,gastrointestinal decompression,correcting water and electrolyte disturbance,acid-suppressing,anti-infective and nutritional support）and SS ;patients in observation group were given PGE1 on the basis of the treatment of control group.The clinical efficacy of the two groups was compared.Results The symptoms alleviating time,remission time of signs,resumed eating time and the average length of stay of observation group were significantly shorter than those of control group（P ＜ 0.05） ; Blood amylase decreased more significantly in observation group after treatment for 3 d,5 d and 7 d,serum calcium rose more obviously after treatment for 2 d,3 d,5 d and 7 d,there were significant differences between the two groups （P ＜ 0.05） ; The curative rate and total effective rate were 30.0％ and 95.0％ in observation group,while they were 10.5 ％ and 78.9％ in control group （P ＜ 0.05）.There was no significant difference in the adverse reactions between the two groups （P ＞ 0.05）.Conclusion SS combined with PGE1 in the treatment of severe acute pancreatitis is significantly better than single use of SS,it is worthy of clinical application.
出处
《实用药物与临床》
CAS
2013年第8期741-743,共3页
Practical Pharmacy and Clinical Remedies
