摘要
目的系统评价喜炎平注射液治疗儿童手足口病的疗效和安全性。方法通过检索中国期刊全文数据库、中文科技期刊全文数据库、万方数据库收集喜炎平注射液治疗手足口病的随机对照试验文献,用Jadad评分表评价纳入文献的质量,用RevMan 5.0软件对纳入的文献进行Meta分析。结果最终纳入文献共11篇,共计病例数1241例,Meta分析结果显示,喜炎平注射液加基础治疗与利巴韦林注射液加基础治疗相比,退热时间缩短1.85天,退疹时间缩短1.51天,总病程时间缩短2.55天,并且均有统计学意义(P<0.00001),尚未见报道喜炎平注射液相关的严重不良反应。结论喜炎平注射液治疗手足口病临床疗效明确,且未见严重不良反应,但尚需设计严谨的随机对照试验来进一步验证。
Objective To evaluate the efficacy and safety of Xiyanping injection for treating handfoot-mouth disease（HFMD） systematically.Methods Literatures about randomized controlled trials of Xiyanping injection for treating HFMD were collected by China National Knowledge Internet,Chinese science and technology periodical full-text database and ChianInfo.The quality of the literatures was assessed by Jadad rating scale,and the data was analysis by RevMan 5.0 software.Results 11 poor-quality studies were included,involving 1241 participants.Meta-analysis showed that the days of Xiyanping injection combined basic therapy group on fever,rash and total duration were shorter than those of ribavirin combined basic therapy group,and the differences were statistically significant（P 0.0001）.Serious adverse reaction of Xiyanping injection was not showed.Conclusions Xiyanping injection showed better therapeutic effect on HFMD.But the quality of the trials is poor.And standard study may be needed.
出处
《环球中医药》
CAS
2013年第8期585-588,共4页
Global Traditional Chinese Medicine
基金
国家中医药管理局2009年中医药行业科研专项(200907001-3)
关键词
喜炎平注射液
手足口病
系统评价
META分析
Xiyanping injection
Hand-foot-mouth disease（HFMD）
System evaluation
Meta-analysis
