摘要
目的探讨不完全性川崎病(iKD)患儿急性期细胞免疫和体液免疫功能的变化,及对临床诊治的意义。方法将70例川崎病患儿分为iKD组(35例),完全性川崎病(cKD)组35例,21例腹股沟疝患儿为对照组。分别测定其外周血淋巴细胞亚群(CD3+、CD3+CD4+、CD3+CD8+、CD4+/CD8+、CD19+、自然杀伤细胞)与血清免疫球蛋白(IgG、IgA、IgM)水平变化,比较3组间的差异。结果与对照组比较,iKD组与cKD组CD4+、CD4+/CD8+、CD19+、IgG、IgA、IgM水平升高(P<0.05),CD8+细胞、自然杀伤细胞水平下降(P<0.05);iKD组与cKD组CD4+/CD8+、CD3+水平比较差异有统计学意义(P<0.05)。结论 iKD患儿急性期同样存在免疫系统高度活化,但其细胞免疫活化程度不如cKD者显著。
Objective To analyze the cellular and humoral immunity condition in children with incomplete Kawasaki disease （iKD）. Methods Seventy children with KD were divided into three groups, i. e. iKD group （n = 35） cKD group （ n = 35 ） , inguinal hernia control group （n = 21 ）. The level variation of lymphocyte subsets （CD3 ＋, CD3 ＋ CD4＋, CD3 ＋ CD8 ＋, CD4＋/CD8 ＋, CD19＋ NK cell） and humoral immunity （ IgG, IgA, IgM） were compared among three groups. Results Compared with the control group, the level of CD4＋, CD4＋/CD8＋, CD19＋, IgG, IgA, IgM increase （P 〈0. 05） in the children with iKD or cKD, the level of CD8 ~ , NK cell decreased （ P 〈 0. 05 ） at the same time. There was statistical difference of CD4 ＋/CD8 ~ in iKD and cKD （ P 〈 0. 05 ）. Conclusions Children in the acute period of iKD have active function in cellular and humoral immunity, the level of active function in cellular immunity is not significant as the ones of cKD.
出处
《新医学》
2013年第9期636-638,共3页
Journal of New Medicine
