摘要
目的 观察纳洛酮对红细胞 β -内啡呔 (RBC - β -EP)红细胞免疫粘附功能 (RCIA)的影响 ,进一步探讨纳洛酮对急性脑梗死患者的作用机制。方法 急性脑梗死患者 48例 ,均发病为 48h以内 ,随机分为纳洛酮组 (纳洛酮 4 0mg加5 %葡萄糖盐水中 5 0 0ml) ,对照组 (10 %川芎注射液 30ml加入低分子右旋糖酐 5 0 0ml) ,每日一次 ,14天一疗程。测定治疗前后BRC -C3bRR ,RBC -ICR ,RBC - β -EP含量。 结果 两组治疗前后临床均有效 ,但纳洛酮组较对照组RBC -C3bRR升高明显 ,RBC - β -EP、RBC -ICR下降明显。结论 表明纳洛酮能阻断过多 β -EP与红细胞膜β -EP受体结合 。
Objective To investigate the effect of Naloxone on RBC-β-EP and RCIA in patients with acute cerebral infarction (ACI) and the therapeutic mechanism of Naloxone on ACI.Methods 48 cases with ACI occurred within 48 hours were randomly divided into two groups-Naloxone group(4.0 mg daily) and control.RCIA and RBC-β-EP were measured before the treatment and after 14 days of treatment.Results The clinic effect in both groups were similar,but RBC-C 3bRR increased while RBC-β-EP and RBC-ICR decreased much more in Naloxone group than in control.Conclusion Naloxone can block the combination of β-EP with β-EP receptor on the RBC membrane,and contributes to improve the function of RCIA in patients with ACI. [
出处
《中国急救医学》
CAS
CSCD
北大核心
2000年第11期656-657,共2页
Chinese Journal of Critical Care Medicine
