摘要
目的:检测KISS-1基因在胃癌中的表达,探讨它与胃癌的临床特征、复发和转移的关系。方法:随机选取2008年菏泽市立医院手术切除的胃癌根治标本50例,采用免疫组化法检测50例胃癌组织中KISS-1基因的表达情况,与正常胃组织做对比,结合临床资料与随访资料进行统计学分析。结果:胃癌组织KISS-1基因的阳性表达率32%,KISS-1基因在低分化、有淋巴结转移、远处脏器转移肿瘤中表达显著降低P<0.05,5年生存者的KISS-1基因阳性表达率明显高于5年内死亡者,P<0.05。结论:KISS-1在胃癌组织中的表达明显低于胃正常组织,表明胃癌的发生可能与KISS-1基因的缺失有关。KISS-1在胃癌组织中的表达与患者的年龄、Borrmann分型、肿瘤的大小、部位、病理类型无显著相关性,而与胃癌的分化程度、浸润深度、淋巴结转移有关。KISS-1基因可能成为预测胃癌恶性潜能的新的生物学标记物,通过恢复和提高体内基因表达水平有望成为胃癌基因治疗的新途径。
Objective：To study the relationship between KISS - 1 gene and the clinic character, relapse, metastasis in gastric cancer through detecting the expression in gastric cancer. Methods： A total of 50 patients post operation paraffin specimens were selected, all samples were analyzed by immunohistoehemical method, the expression of KISS - 1 gene was contrasted with normal gastric mucosas. Results ： The positive rate of KISS - 1 gene in gastric cancer was 32%. The expression of KISS - 1 in cancers with low - grade differentiation and lymph node metastasis was evidently lower（ P 〈 0.05 ）, the positive expression rate of KISS - 1 in the patients who survived more than 5 years was higher than that of in the patients who survived less than 5 years. （ P 〈 0.05 ）. Conclusion： The expression of KISS - 1 in gastric cancer is lower than in normal gastric mucosas, it indicated the occurrence of gastric cancer is related with the absence of KISS - 1. The expression of KISS - 1 in gastric cancer was not correlative with age borrmann type, tumor size,site, pathological type, but was related with differentiation degree, invasive depth, lymph node metastasis. The gene KISS - 1 may be a new biological marker which can predict the malignant potential of gastric cancer.
出处
《现代肿瘤医学》
CAS
2013年第10期2289-2291,共3页
Journal of Modern Oncology
