摘要
目的探讨非酒精性脂肪性肝病（NAFLD）严重程度与代谢综合征组分的相关性。方法选择2011年3月至2012年8月福建医科大学附属泉州第一医院诊断为NAFLD患者127例，其中轻度NAFLD61例（轻度NAFLD组）、中度NAFLD45例（中度NAFLD组）、重度NAFLD21例（重度NAFLD组）。另选择21例同期就诊的非脂肪肝患者作为对照组。所有研究对象均由专人测量身高、体质量、腰围、血压；接受肝脏超声波检查及空腹血糖、血脂、肝功能等检测。结果对照组与轻、中、重度NAFLD组合并超重的比例依次为57．1％（12／21）、88．5％（54／61）、95．6％（43／45）、100％（21／21），差异有统计学意义（X2=18．376，P〈0．001）；各组合并肥胖的比例依次为19．0％（4／21）、44．3％（27／61）、64．4％（29／45）、71．4％（15／21），差异有统计学意义（x2=16．440，P=0．001）；各组合并腹部肥胖的比例依次为38．1％（8／21）、85．2％（52／61）、97．8％（44／45）、95．2％（15／21），差异有统计学意义（X2=32．516，P〈0．001）。对照组与轻、中、重度NAFLD组中合并代谢综合征比例依次为14．3％（3／21）、45．9％（28／61）、71．1％（32／45）、71．4％（15／21），差异有统计学意义（X2=22．637，P〈0．001）；轻、中、重度NAFLD组分别与对照组比较差异均有统计学意义（x2=6．641，P〈0．05；X2=18．562，P〈0．05；X2=14．000，P〈0．05）。NAFLD严重程度与体质量指数、腰围、甘油三酯、空腹血糖、收缩压、舒张压呈显著正相关（r=0．467、0．503、0．386、0．369、0．279、0．295，P均〈0．01）；NAFLD严重程度与高密度脂蛋白胆固醇呈显著负相关（r=-0．209，P〈0．05）。结论NAFLD严重程度与代谢综合征的组分有显著相关性。
Objective To investigate the relationships between the severity of non-alcoholic fatty liver disease （NAFLD） and metabolic syndrome （MS）. Methods One hundred and twenty-seven cases of NAFLD patients were selected from March 2011 to August 2012 in the First Hospital Affiliated to Fujian Medical University ,of them,61 patients with mild NAFLD ,45 patients with moderate and 21 patients with severe. And 21 cases without NAFLD were selected as control group during the same hospitalized period. All objects received the measures of height, body weight, waist circumference （ WC ）, blood pressure ; Liver ultrasonic examination, the examination of fasting plasma glucose, blood fat and hepatic function detections were also handed by special people. Results The proportion of overweight in the control group and the three NAFLD subgroups were 57. 1% （ 12/21 ）, 88.5% （ 54/61 ）, 95. 6% （43/45） and 100% （ 21/21 ） respectively （ X2 = 18. 376, P 〈 0. 001 ） ;The proportion of the obesity in control group and the three NAFLD subgroups were 19. 0% （4/21）, 44.3 % （ 27/61 ） ,64.4% （ 29/45 ） and 71.4% （ 15/21 ） respectively（ X2 = 16. 440, P = O. 001 ）. The proportion of the metabolic syndrome of the control group and the three NAFLD subgroups were 14. 3% （3/21）,45.9% （28/61） ,71.1% （32/45） and 71.4% （ 15/21 ） respectively （X2 =22. 637 ,P 〈 0. 05 ）. All three subgroups of NAFLD were higher than the control group （ X2 = 6. 641, P 〈 0. 05 ; X2 = 18. 562, P 〈 0. 05 ; X2 = 14. 000, P 〈 0. 05, respectively）. The severity of NAFLD was positively correlated with BMI, WC, TG, FBG, SBP, and DBP （ r = 0. 467,0. 503,0. 386,0. 369, 0. 279, 0. 295, P 〈 0.01 ）, and negatively correlated with HDL-C （ r = - 0. 209,P 〈 0.05 ）. Conclusion The severity of NAFLD had significant correlations with metabolic syndrome＇s components.
出处
《中国综合临床》
2013年第11期1158-1161,共4页
Clinical Medicine of China
基金
福建省泉州市第二批技术研究与开发项目（2010221）
关键词
非酒精性脂肪性肝病
代谢综合征
相关性分析
Non-alcoholic fatty liver disease
Metabolism syndrome
Correlation analysis
