摘要
目的水凝胶是含水量高和体表面积大的化学性惰性合成高分子,当植入到脊髓组织中,为细胞和轴突提供力学支持。本研究对修复脊髓损伤水凝胶制备、物理特性进行研究。方法本研究交联的水凝胶由2-甲基丙烯酸羟(HEMA)-2乙基三甲基氯化物(methacryloyloxy,MOETACL)共聚物合成。利用氯化钠(NaCl)微粒制备水凝胶的孔隙,用扫描电子显微镜观察其结构。结果计算水凝胶在单位体积上的孔隙数,孔的平均直径和平均体积。以HEMA-MOETACL为基础的水凝胶在其组成上具有显著特征。结论均质多孔的水凝胶,其在修复脊髓损伤的生物特性上具有显著特征。
Objective Study on preparation and physical properties of HEMA-MOETACL. Methods Crosslinked hy drogels is made of 2-methyl acrylic acid hydroxy (HEMA) and 2-ethyl trimethyl ammonium chloride (methacryloyloxy, MOETACL) copolymer synthesis. The pore of Hydrogels is the use of sodium chloride (Nacl) particles. Scanning electron microscope is observed its structure. Results Hydrogels are calculated on a unit volume of pore number mean diameter and mean size of the hole. Hydrogels are calculated on a unit volume of pore number, the average diameter of hole and the average volume. HEMA-MOETACL gel also has significant features in its chemical composition. Conclusion Homogeneous porous hydrogels has biological characteristics in the repair of spinal cord injury.
出处
《生物骨科材料与临床研究》
CAS
2013年第5期9-12,66,共5页
Orthopaedic Biomechanics Materials and Clinical Study
基金
国家自然科学基金(81071486)
陕西省自然科学基金(SJ08ZT12-2)
陕西省科技攻关项目(2009K18-02)
关键词
水凝胶
脊髓损伤
生物材料
Hydrogel
Spinal cord injury
Biological material