期刊文献+

修复脊髓损伤的仿生多孔水凝胶的制备研究 被引量:3

Study on preparation of repair of spinal cord injury with hydrogel
在线阅读 下载PDF
导出
摘要 目的水凝胶是含水量高和体表面积大的化学性惰性合成高分子,当植入到脊髓组织中,为细胞和轴突提供力学支持。本研究对修复脊髓损伤水凝胶制备、物理特性进行研究。方法本研究交联的水凝胶由2-甲基丙烯酸羟(HEMA)-2乙基三甲基氯化物(methacryloyloxy,MOETACL)共聚物合成。利用氯化钠(NaCl)微粒制备水凝胶的孔隙,用扫描电子显微镜观察其结构。结果计算水凝胶在单位体积上的孔隙数,孔的平均直径和平均体积。以HEMA-MOETACL为基础的水凝胶在其组成上具有显著特征。结论均质多孔的水凝胶,其在修复脊髓损伤的生物特性上具有显著特征。 Objective Study on preparation and physical properties of HEMA-MOETACL. Methods Crosslinked hy drogels is made of 2-methyl acrylic acid hydroxy (HEMA) and 2-ethyl trimethyl ammonium chloride (methacryloyloxy, MOETACL) copolymer synthesis. The pore of Hydrogels is the use of sodium chloride (Nacl) particles. Scanning electron microscope is observed its structure. Results Hydrogels are calculated on a unit volume of pore number mean diameter and mean size of the hole. Hydrogels are calculated on a unit volume of pore number, the average diameter of hole and the average volume. HEMA-MOETACL gel also has significant features in its chemical composition. Conclusion Homogeneous porous hydrogels has biological characteristics in the repair of spinal cord injury.
出处 《生物骨科材料与临床研究》 CAS 2013年第5期9-12,66,共5页 Orthopaedic Biomechanics Materials and Clinical Study
基金 国家自然科学基金(81071486) 陕西省自然科学基金(SJ08ZT12-2) 陕西省科技攻关项目(2009K18-02)
关键词 水凝胶 脊髓损伤 生物材料 Hydrogel Spinal cord injury Biological material
  • 相关文献

参考文献20

二级参考文献163

共引文献84

同被引文献40

  • 1李志军,陈捷,杨黎明,王涛,王胜,孙婕.聚丙烯酰胺/聚异丙基丙烯酰胺互穿网络水凝胶的制备与性能(英文)[J].化学研究,2005,16(4):6-9. 被引量:1
  • 2卢国冬,燕青芝,宿新泰,刘中清,葛昌纯.多孔水凝胶研究进展[J].化学进展,2007,19(4):485-493. 被引量:40
  • 3杨蓉,黄星,吴小蔚.聚丙烯酰胺水凝胶注射隆鼻后继发鼻畸形的分析与处理[J].中国组织工程研究与临床康复,2007,11(26):5234-5236. 被引量:4
  • 4THURET S,MOON L,GAGE F.Therapeutic interventions after spinal cord injury[J].Nat Rev Neurosci,2006,7(8):628-643.
  • 5TAM R Y,TOBIAS F,NIKOLAOS M,et al.Regenerative therapies for central nervous system diseases:a biomaterials approach[J].Neuropsychopharmacology,2014,39(1):169-188.
  • 6PATHAN S A,IQBAL Z,ZAIDI S M,et al.CNS drug delivery systems:novel approaches[J].Recent Pat Inflamm Allergy Drug Discov,2009,3(1):71-89.
  • 7PIANTINO J,BURDICK J,GOLDBERG D,et al.An injectable,biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injury[J].Exp Neurol,2006,201(2):359-367.
  • 8MACAYA D,SPECTOR M.Injectable hydrogel materials for spinal cord regeneration:a review[J].Biomed Mater,2012,7(1):12001.
  • 9HENISE J,HEARN B R,ASHLEY G W,et al.Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system[J].Bioconjugate Chem,2015,26(2):270-278.
  • 10WEI S T,XIAN J L.Advances in hydrogel delivery systems for tissue regeneration[J].Mater Sci Eng C Mater Biol Appl,2014,45:690-697.

引证文献3

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部