摘要
目的观察骨化三醇用于已经血液透析患者继发性甲旁亢常规疗法与冲击疗法疗效,并对冲击疗法的有效性和安全性进行验证。方法将50例尿毒症已经血液透析继发性甲状旁腺功能亢进患者随机分为两组,对照组25例采用常规剂量骨化三醇治疗,治疗组25例采用骨化三醇冲击治疗,比较观察两组的主要临床指标变化。结果治疗组的有效率高于对照组,两组比较差异有统计学意义(P<0.05),治疗组甲状旁腺激素(PTH)、磷(P))水平明显下降,钙(Ca)水平明显升高,与治疗前比较差异有统计学意义(P<0.05)。治疗组治疗后PTH、P水平低于对照组(P<0.05),Ca水平高于对照组(P<0.05)。结论骨化三醇冲击治疗尿毒症继发性甲状旁腺功能亢进临床疗效显著,无严重不良反应,安全有效。
Objective To observe the clinical efficacy of calcitriol pulse therapy or routine therapyon hemodialysis patients with secondary hyperparathyroidism, and verify the validity and security of pulse therapy method. Methods The 50 uremic patients received hemodialysis but with secondary hyperparathyroidism were divided into the treatment group （n = 25 ） and the control group （n = 25 ） randomly. Patients in treatment groupwere given pulse therapy with calcitriol, patientsin contrlo group were given routine therapy with calcitriol. The main clinical indexs of the two groups was observed and compared. Results The effective rate of treatment group was higher than control group, thedifference was statisticallysignificant （ P 〈 0. 05 ）. The concentration of parathyroid hormone （PTH） and phosphorus （P） declined obviously while the level of calcium （Ca） increased compared to the levels before the treatment （ P 〈 0.05 ）. The level of PTH and P in the treatment group were significantly lower than the control group after treatment（P 〈0. 05）, but the level of Ca was higher than control group （ P 〈 0.05 ）. Conclusions The clinical efficacy of pulse therapy with calcitriolon the treatment of uremic patients with secondary hyperparathyroidismis distinct, and calcitriol is a drugthat is safe and effective for secondary hvnemarathvroidismwithoiJt serious adverse reactions.
出处
《齐齐哈尔医学院学报》
2013年第18期2665-2666,共2页
Journal of Qiqihar Medical University
