摘要
目的探讨肿瘤患者外周血T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)的变化及临床价值。方法测定100例肿瘤患者,其中肺癌40例,消化道肿瘤40例,其他肿瘤20例;及90名正常对照组外周血T淋巴细胞亚群绝对计数、免疫球蛋白(IgG、IgA、IgM),比较与正常对照组间差异。结果肿瘤患者组T淋巴细胞外周血绝对计数CD3+[(1 041±358)个/μL]、CD4+[(689±263)个/μL]、CD4+/CD8+比值(1.15±0.40)与健康组比较明显下降(P<0.05);CD8+[(602±223)个/μL]与健康组比较略有升高(P>0.05)。肿瘤患者组IgG、IgA、IgM均高于对照组。结论肿瘤患者存在免疫功能异常,T淋巴细胞亚群绝对计数的变化对肿瘤患者病情监测及预后判断具有重要意义。
Objective To investigate the changes of peripheral blood T lymphocyte subsets （ CD3 ＋ , CD4＋ , CD8＋ and CD4＋/CD8＋ ） in patients with tumor and the clinical significance. Methods A total of 100 patients with tumor （ including 40 patients with lung cancer, 40 patients with gastrointestinal cancer and 20 patients with other tumors） and 90 healthy controls were enrolled. Peripheral blood T lymphocyte subsets＇ absolute counts and immunoglobulin （IgG, IgA and IgM） were determined. The differences between the 2 groups were analyzed statistically. Results T lymphocyte subsets＇ absolute counts were CD3＋ [ （1 041 ± 358）/μL], CD4＋ [ （689 ± 263 ）/μL], CD4＋/CD8＋ ratio （1.15 ±0.40） in tumor group, which were significantly lower than those in control group （P 〈 0.05 ）, and CD8＋ [ （602± 223 ）/μL ] increased slightly compared with that in control group （P 〉 0.05 ）. IgG, IgA and IgM were higher in tumor group than in control group. Conclusions Tumor patients have immune dysfunction, and the changes of T lymphocyte subsets＇ counts have significance on the monitoring and prognosis in patients with tumor.
出处
《检验医学》
CAS
2013年第10期901-903,共3页
Laboratory Medicine
基金
上海市科委重点科技攻关项目(10441900200)
