摘要
目的探讨心型脂肪酸结合蛋白(H-FABP)在急性心肌梗死(AMI)院前早期诊断中的价值,为院前AMI的诊断提供参考指标。方法疑似AMI患者128例,院前定性测定胸痛患者H-FABP,入院即刻测定其心肌肌钙蛋白(cTnI),以急诊PCI术中造影结果或冠状动脉CT血管成像结果为诊断标准,统计分析其诊断的敏感度、特异度、阴性预测值及阳性预测值,并与院内测定的心肌肌钙蛋白测定结果比较。结果院前测定急救胸痛患者H-FABP的敏感度、特异度分别为76.47%(65/85)、72.09%(31/43),入院即刻测cTnI的敏感度、特异度分别为38.82%(33/85)、79.06%(34/43);联合H-FABP与cTnI联合诊断结果显示,其敏感度、特异度、阳性预测值及阴性预测值分别为80.95%(17/21)、83.33%,(30/36)、73.91(17/23)和88.23%(30/34),各项指标均较高。结论 H-FABP有望作为院前急性心肌梗死监测的一项快速、准确、敏感、特异性的指标。
Objective To investigate the significance of heart type fatty acid binding protein（H-FABP） for the early diagnosis of acute myocardial infarction（AMI） in pre hospital.Methods Patients suffered from chest pain as the main syndrome were enrolled in the study.Then H-FABP were detected in pre hospital,and selected with PCI,CTA results and follow up data after as the diagnostic criteria.H-FABP and cTnI were determined and conducted statistical analysis in early period of AMI.Results The sensitivity and specificity of H-FABP were 76.47%（65/85） and 72.09%（31/43）.Compared with cTnI,H-FABP showed higher sensitivity（38.82%,33/85） and specificity（79.06%,34/43）,and combining H-FABP with cTnI,the sensitivity（80.95%,17/21）,specificity（83.33%,30/36）,positive（73.91%,17/23） and negative（88.23%,30/34） predictive values indicated the combination had the highest value in diagnosis of AMI in pre hospital.Conclusion HFABP is one of the most useful methods in the early diagnosis of AMI in pre hospital rescue.
出处
《疑难病杂志》
CAS
2013年第11期838-840,共3页
Chinese Journal of Difficult and Complicated Cases
基金
青岛市公共领域科技支撑计划项目[No.11-2-3-5-(9)-nsh]
关键词
急救
院前
胸痛
脂肪酸结合蛋白质类
心肌梗死
诊断
Rescue pre hospital Chest pain Heart type fatty acid binding protein Myocardial infarction Diagnosis
