摘要
白蛋白纳米粒作为一种新型制剂,显示出独特的靶向肿瘤机制,且本身具有可生物降解、无毒、无抗原性、病人耐受等特点而表现出良好的应用前景。该文通过对白蛋白纳米粒国内外研究近期文献的归纳整理,较为系统的介绍了白蛋白纳米粒及其制备工艺、质量评价、药代动力学研究等。
AThe novel formulation of albumin nanoparticles is promising in clinical application because it has a unique mechanism of targe ting tumor cells and also it is inherently biodegradable, non-toxic, non-antigenic and Well tolerated in patients. Based on recent literatures of domestic and international research on albumin nanoparticles, this article provides an overview of albumin nanoparticles including the preparation procedure, quality evaluation and pharmacokinetic studies, etc.
出处
《安徽医药》
CAS
2013年第10期1649-1651,共3页
Anhui Medical and Pharmaceutical Journal
基金
十二五国家"重大新药创制"科技重大专项项目(No2012ZX09401006)
关键词
白蛋白纳米粒
肿瘤靶向
制备工艺
质量评价
albumin nanoparticles
tumor targeting
preparation procedure
quality evaluation
