摘要
目的 探讨nm23蛋白在骨巨细胞瘤(GCT)的表达及其与GCT病理分级和复发的关系。方法 应用SP免疫组织化学方法检测nm23在52例GCT(按Jaffe分级：Ⅰ级15例、Ⅱ级25例、Ⅲ级12例)中的表达。 结果 21例nm23表达呈阳性，总阳性率为40.4%，在Ⅰ级、Ⅱ级、Ⅲ级中的阳性表达率分别为33.3%、44.0%、41.7%，nm23阳性表达在骨巨细胞瘤Ⅰ级、Ⅱ级、Ⅲ级中差异无显著性(χ2=0.45，P>0.05)。在术后3年内出现复发的13例中，有9例阳性表达，无复发的39例中有12例阳性表达，两者差异显著(χ2=5.99，P<0.05)。结论 nm23在GCT中的表达与病理分级无关，但与其复发有关。
Objective：To investigate the relationship of nm23 prot ein expression with pathological types and recurrence of human giant cell tumors of bone. Meth ods： Polyclonal antibodies against nm23 protein were used to measure expressio n of this protein in the cytoplasm from sections of the giant cell tumor of bone . Results: Twenty-one of 52 cases tumors expressed nm23 protein. 33.3% of the gr ade I, 44.0% of the gradeⅡ and 41.7% of the grade Ⅲ giant cell tumor of bone showed p ositive for nm23 protein. Positivity for nm23 were found in 69.2% of the recurrenc e cases and in 30.8% of the no recurrence cases. A positive relationship exists between the recurrence and nm23 protein positivity. However, there was no associati on between nm23 positivity and pathological types.Conclusion: There was a sta tistically significant correlation between the expression of nm23 pro tein and the recurrence in the giant cell tumor of bone.(x2=5.99，P<0.05)。
基金
湖南省科委资助课题
关键词
NM23
免疫组织化学
骨巨细胞瘤
复发
nm23 Protein
immunohistochemistry
gian t cell tumor of bone
recurrence
