摘要
目的：了解2型糖尿病人群DNA氧化损伤的情况。方法：采用酶联免疫吸附法（ELISA）检测，健康人群和2型糖尿病人群尿样DNA中8-OHdG的含量。结果：尿样DNA中的8-OHdG水平显示，高于半年病程2型糖尿病病例和2型糖尿病伴肾病病例分别为（22．37±5．62）ng／mgGr和（23．80±7．58）ng／mgGr，明显高于健康人的（15．74±6．10）ng／mgGr（P〈0．05）。结论：高于半年病程2型糖尿病病例和2型糖尿病伴肾病病例的DNA氧化损伤水平均高于健康人群。对于预防和监测2型糖尿病病人，测定尿样中8-OHdG含量是一个简单、准确的方法。
Objective： To know the situation of oxidation damnification of DNA of type 2 diabetic patients. Methods： Urine 8-OHdG concentrations of healthy people and type 2 diabetic patients were conducted with the use of ELISA. Results： The content of urine 8-OHdG of hyper-half year course of diseases of type 2 diabetic patients was 22.37±5.62 ng/mgGr,of type 2 diabetic patients with nephropathy was 23.80±7.58 ng/mgGr. There were higher than that healthy people was 15.74 ± 6.10 ng/mgGr （P〈0.05）. Conclusions： The level of oxidation damnification of DNA, hyper-half year course of diseases of type 2 diabetic patients and type 2 diabetic patients with nephropathy were higher than healthy people. The method was simple,accu-rate for preventing and supervising type 2 diabetic patients of urine 8-OHdG concentrations.
出处
《河南中医》
2013年第B04期298-298,共1页
Henan Traditional Chinese Medicine
