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慢性肾脏病患者尿蛋白定量分析的临床应用价值

Clinical significance of Chronic kidney disease patients with urinary protein composition analysis
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摘要 目的:探讨尿ALB,α1—MG和IgG及轻链(Kx)检测在慢性肾脏病(CKD)中的临床应用价值。方法:选择我院2011年8月至2012年11月健康者24例,同期住院慢性肾衰患者(CKD4期和5期)33例,肾病综舍征患者(CKD1期和2期)21例,采用速率散射比浊法检测晨尿ALB,α1—MG和IgG厦轻链,并进行统计学分析。结果:慢性肾衰(cRF)和肾病综合征(Ns)患者尿ALB,α1—MG,IgG及轻链(n)含量与正常对照组比较均有显著差异(P〈0.001);CRF患者尿a1-MG含量高于NS患者(P=0.004),尿ALB的含量低Ns患者,有统计学意义(P〈0.001),CRF与NS患者尿IgG及轻链(κλ)含量无明显差异(P〉0.05)。结论:CRF和NS患者尿ALB,α1-MO和IgG及轻链(κλ)含量增高,反映患者可能同时存在肾小球和肾小管的损伤,CRF患者肾小管损伤较重,对慢性肾脏病诊断、治疗和病情监测具有重要临床意义。 Objective : Study clinical application of chronic kidney disease(CKD) patients urine ALB, α 1-MG and IgG and light chain (kappa lambda) detection. Method: Choose our hospital from 2011 August to 2012 November, 24 cases of healthy person, In the same period 33 cases of Chronic renal failure(CKD 4 period and the 5 period), 21 cases of Nephrotic syndrome(CKD 1 period and the 2 period) ,By rate nephelometry test urine ALB,α1-MG and IgG and light chain (kappa lambda) Content, and make a statistical analysis. Result: CRF and NS patients Urine ALB,α1-MG and IgG and light chain (kappa lambda) content compared with the normal control group with Significant difference(P〈0. 001) ; CRF patients Urine α1-MG content is higher than that of NS patients(P=0. 004), The urine ALB content was lower in patients with NS, with statistical significance(P〈0. 001). CRF and NS patients Urinary IgG and light chain (kappa lambda) had no significant difference(P〉0. 05). Conclusion:CRF and NS patients urine ALB,α1-MG and IgG and light chain (kappa lambda) content increased, Reflect the patient may exist at the same time the glomerular and renal tubular injury, CRF pa-tients renal tubular injury is heavy, In chronic kidney disease diagnosis,treatment and condition monitoring has important clinical significance.
出处 《河南中医》 2013年第B04期318-319,共2页 Henan Traditional Chinese Medicine
关键词 慢性肾脏病 肾病综合征 慢性肾衰 尿蛋白 Chronic kidney disease(CKD) Chronic renal failure(CRF) Nephrotie syndrome(NS) Urinary protein
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