摘要
目的 观察胃癌组织中结肠癌转移相关基因1（MACC1）和热休克蛋白90（HSP90）的表达,探讨两者与胃癌临床病理学指标之间的关系.方法 应用免疫组织化学法检测56例胃癌患者手术切除的癌组织和癌旁组织中MACC1和HSP90表达水平.结果 MACC1在胃癌组织中表达率为69.64％（39/56）,在癌旁组织中的表达率为7.14％（4/56）,两者差异有统计学意义（P＜0.01）；HSP90在胃癌组织中表达率为64.29％（36/56）,在癌旁组织中的表达率为5.36％（3/56）,两者差异有统计学意义（P＜0.01）.MACC1表达水平与胃癌浆膜浸润、肿瘤大小、TNM分期、淋巴结转移有关（P＜0.05）,HSP90表达水平与胃癌浆膜浸润、TNM分期、淋巴结转移有关（P＜0.05）.结论 MACC1和HSP90有可能成为判断胃癌生物学行为的参考指标.
Objective To study the expression of metastasis-associated in colon cancer 1 （MACC1） and heat shock protein 90 （HsPg0） in gastric carcinoma, and their relation to the elinicopatho- logical features. Methods MACC1 and HSPg0 expression in 56 cases of human gastric carcinoma tissues and non-cancerous adjacent coloreetal tissues was examined by using immunohistochemical method. Results The expression rate of MACC1 protein was 69.64% （39/56） in gastric carcinoma tissues, and 7. 14% （4/56） in non-cancerous adjacent gastric tissues （P 〈0. 01 ）. The expression rate of HsPg0 was 64.29% （36/56） in gastric carcinoma tissues, and 5.36% （3/56） in non-cancerous adjacent gastric tissues （P 〈 0. 01）. The expression of MACC1 was related to tumor size, histologie type, TNM stage and lymph node metastasis of gastric carcinoma （ P 〈 0. 05 ） , and there was a close correlation between the expression of HSP90 and tumor size, TNM stage and lymph node metastasis （P 〈 0. 05 ）. Conclusion MACC1 and HSPg0 may be potentially useful for assessing the biological behaviors of gastric carcinoma.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2013年第11期2411-2413,共3页
Chinese Journal of Experimental Surgery
关键词
结肠癌转移相关基因1
热休克蛋白90
胃癌
免疫组织化学
Metastasis-associated in colon cancer 1
Heat shock protein 90
Gastric carcino-ma
Imrnunohistochemistry
