摘要
目的分析医院重症监护病房(ICU)铜绿假单胞菌的分布与耐药性,为临床医师合理用药提供依据。方法采用纸片扩散法对2008年1月-2011年12月ICU分离的243株铜绿假单胞菌进行药敏监测,并统计分析铜绿假单胞菌对临床常用抗菌药物的耐药率。结果临床分离的243株铜绿假单胞菌主要来源于呼吸道标本,占88.5%,铜绿假单胞菌对头孢哌酮/舒巴坦耐药率最低,为8.0%,其次依次为阿米卡星、头孢他啶、头孢吡肟、哌拉西林/他唑巴坦、氨曲南、哌拉西林,耐药率分别为17.6%、22.9%、24.5%、32.5%、36.4%、36.7%;碳青霉烯类药物亚胺培南、美罗培南耐药率分别为44.0%和41.9%。结论铜绿假单胞菌是医院感染的主要病原菌之一,应重视耐药菌株的监测,预防和控制医院感染的发生。
OBJECTIVE To analyze the distribution and drug resistance of Pseudomonas aeruginosa in intensive care unit （ICU） so as to guide the reasonable clinical use of antibiotics. METHODS The drug susceptibility testing was performed with the use of disc diffusion method for 243 strains of P. aeruginosa which were isolated from ICU during Jan 2008 -- Dec 2011, and the drug resistance rates of the P. aeruginosa strains to 14 commonly used antibiotics were statistically analyzed. RESULTS Of totally 243 strains of clinical isolates of P. aeruginosa, 88.5 were isolated from the respiratory tract specimens. The drug resistance rate of the strains to cefoperazone- sulbactam was the lowest （8.0%）, the drug resistance rates to amikacin, eeftazidime, eefepime, piperacillin- tazobaetam, aztreonam, and piperacillin were 17.6%, 22.9%, 24.5%, 32.5%, 36.4%, and 36.7%, respectively, and the drug resistance rates to such carbapenems antibiotics as imipenem and meropenem were 44.0% and 41.9 %, respectively. CONCLUSION The P. aeruginosa is one of the main species of pathogens causing nosocomial infections, and great importance should be attached to the surveillance of drug resistant strains so as to prevent and control the nosocomial infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第22期5551-5552,5555,共3页
Chinese Journal of Nosocomiology
基金
青岛市公共领域科技支撑计划基金项目(11-2-3-5-(6)-nsh)
关键词
重病监护病房
铜绿假单胞菌
耐药性
Intensive care unit
Pseudomonas aeruginosa
Drug resistance
