摘要
目的探讨欣母沛预防前置胎盘剖宫产术后出血的效果。方法选择2009年9月至2011年8月在我院产科就诊的前置胎盘产妇221例作为研究对象,按随机数字表法分为对照组和观察组。两组产妇均实施剖宫产术,对照组胎儿娩出后立即在给予缩宫素20 U注射在子宫壁上,同时给予缩宫素20 U+500 mL生理盐水持续静脉滴注;观察组在对照组治疗的基础上给予欣母沛250μg,子宫壁注射。所有患者产后均给予常规用药及护理。比较两组患者产后2 h内和产后24 h内的累计出血量、产后胎盘自行剥离的患者比例与所需时间,以及不良反应发生率。结果产后2 h和24 h的累计出血量,观察组分别为(241.8±15.4)mL和(304.5±16.1)mL;对照组分别为(402.4±16.3)mL和(466.7±16.7)mL,观察组均显著低于对照组(P<0.05)。观察组胎盘自行剥离72例(65.5%),所需时间为(5.3±2.6)min;对照组胎盘自行剥离52例(46.8%),所需时间为(8.9±3.5)min,观察组胎盘自行剥离率优于对照组,而所需时间少于对照组,两组比较差异均有统计学意义(P<0.05)。观察组和对照组不良反应发生率分别为7.3%和5.4%,两组比较差异无统计学意义(P>0.05)。结论在前置胎盘产妇中预防性应用欣母沛能显著降低产后出血量,增加胎盘自行剥离率,缩短剥离时间,但未增加不良反应发生率。
Objective To investigate the effect of carboprost tromethamine injection for prevention post- partum hemorrhage led by placenta previa. Methods Two hundred and twenty-one cases of puerperal with placenta previa admitted from September 2009 to August 2011 were selected. The cases were divided into control group and observation group according to random number table method. The control group was given 20 U oxytocin injection into uterine wall immediately after delivery of fetus,at the same time,20 U oxytocin injection added into 500 mL normal saline with continuous intravenous drip. The observation group was given 250 Ixg carboprost tromethamine injection into uterine wall on the basis of control group. All patients were given conventional medicine and nursing after delivery. The cumulative amount of bleeding of the two groups after postnatal within 2 hours and 24 hours, the proportion of postpartum placental separation by itself, the mean time for placental separation by itself, and the incidence rate of adverse reactions after drug usage were compared. Results The cumulative amount of bleeding within 2 hours and 24 hours after delivery were （ 241.8 ± 15.4 ） mL and （ 304.5 ± 16.1 ） mL respectively for the observation group and （402.4 ± 16.3 ） mL and（466.7 ± 16.7 ）mL for control group. The difference of the two groups had statistical significance（ P 〈 0.05 ）. In observation group, the number of patients with placental separation by itself were 72 Cases,the rate was 65.5 % , the time for placental separation by itself was （ 5.3 ± 2.6 ） min, and the number of the control group was 52, the rate was 46.8%, the time was（8.9 ± 3.5 ） min. The indexes of the two groups had statisti- cally significant difference（P 〈 0.05 ）. The adverse reactions incidence rate of the observation group and control group was 7.3 % and 5.4% respectively,with no statistically significant difference（ P 〉 0.05 ）. Con- clusion Prophylactic application of carboprost tromethamine injection for placenta previa can conspicuously decrease the amount of postpartum bleeding, increase the rate and shorten the time of placental separation by itself,without increasing adverse reactions.
出处
《医学综述》
2013年第20期3835-3837,共3页
Medical Recapitulate
关键词
欣母沛
剖宫产
前置胎盘
产后出血
Carboprost tromethamine injection
Cesarean section
Placenta previa
Postpartum hemor- rhage
