摘要
目的观察不同体质指数(BMI)的初诊2型糖尿病(T2DM)患者短期胰岛素泵强化治疗的效果。方法将60例初诊2型糖尿病患者按照BMI≥25 kg·m-2分为肥胖组(OB组)与非肥胖组(NOB组),每组30例。两组均进行1周的胰岛素泵强化治疗,检测入院时空腹血糖(FBG)、空腹胰岛素(FINS)和空腹C肽(FCP),糖化血红蛋白(HbAlc)等生化指标,比较两组血糖达标时间,达标时胰岛素用量以及两组7个时点血糖水平和一日内血糖水平标准差(SDBG)的差异。结果两组血糖达标时间和7个时点的血糖无明显差异,但OB组胰岛素用量明显高于NOB组(P<0.05),而SDBG较NOB组小(P<0.05)。结论初诊肥胖型T2DM患者较非肥胖型T2DM患者血糖波动性较小,胰岛储备功能较好,但是胰岛素用量较大。
Objective To observe the influence of body mass index （BMI） of newly diagnosed type 2 diabetes mellitus （T2DM） on therapeutic effect of short-term insulin pump intensification therapy. Methods 60 cases of newly diagnosed T2DM were assigned into obesity group（ OB group,n =30） and non-obesity group（NOB group,n =30） according to BMI and were treated with insulin pump intensifica- tion therapy for a week. Biochemical indexes such as fasting blood glucose （FBG） , fasting insulin （FINS） , fasting c-peptide （FCP） and glycosylated hemoglobin（HbAlc） were measured before therapy. The therapeutic time, insulin dosage, seven-point blood glucose, the standard deviation of blood glucose（SDBG） were recorded. Results There was no significant difference between two groups in therapeu- tic time and seven-point blood glucose （P 〉 0.05 ）, but insulin dosage in OB group was higher than that in NOB group （P 〈 0.05 ）, while SDBG was lower than that in NOB group （ P 〈 0.05 ）. Conclusions Obese patients with newly diagnosed T2DM have lower blood glucose fluctuations and better insulin reserve function, but they need larger insulin dosage during short-term insulin pump intensification therapy.
出处
《安徽医药》
CAS
2013年第11期1954-1955,共2页
Anhui Medical and Pharmaceutical Journal
关键词
糖尿病
2型
胰岛素泵
体质指数
diabetes, type 2
insulin pump
body mass index
