摘要
目的了解大连市结核分枝杆菌的耐药现状及耐多药情况,为结核病防治对策的制订提供依据。方法收集大连市2012年1年内初治涂阳和复治涂阳病例,对成功分离的540例结核分枝杆菌菌株,用绝对浓度法进行一线抗结核药物药物敏感性实验。结果总耐药率40.9%,初始耐药率37.7%,获得性耐药率51.2%;耐多药率3.5%,其中初始耐多药率2.7%,获得性耐多药率6.9%。结论大连市结核分枝杆菌的耐药发生率较高,应加强对现有治疗管理方法的研究。
Objective To find out the status of drug resistance （DR） of Mycobacterium tuberculosis and multi drug-resistance tuberculosis （MDR） situation in Dalian, to provide evidence for Dalian TB control. Methods To collect all new smear positive cases and retreatment smear positive cases in survey area were the cases for surveillance in 2012. All of 540 isolated strains of mycobacterium tuberculosis were test for the first line drug susceptibility, by the absolute concentration method. Results The over all drug resistance was 40.9%, the primary resistance was 37.7%, and the acquired drug resistance was 51.2%;multi-drug resistance was3.5%,the rates were 2.7% and 6.9% respectively for primary multi-drug resistance and acquired drug resistance .Conclusion The detection rate of drug resistance TB was high in Dalian, We should strengthen the research of treatment and management methods.
出处
《中国医药指南》
2013年第31期370-371,共2页
Guide of China Medicine
关键词
分枝杆菌
结核
耐药性
细菌
大连市
Mycobacterium
Tuberculosis
Drug-resistance
Bacterial
Dalian city
