摘要
目的探讨左侧前额叶背外侧10 Hz重复经颅磁刺激(rTMS)治疗精神分裂症难治性阴性症状的疗效。方法选择41例以难治性阴性症状为主的患者随机分为观察组(n=21)和对照组(n=20),分别给予20次10 Hz左侧前额叶背外侧rTMS真刺激和伪刺激进行治疗,治疗期间维持原有抗精神病药种类及剂量不变。采用阳性和阴性症状量表(PANSS)评估临床症状,采用治疗中不良反应症状量表(TESS)评估不良反应。结果治疗后观察组阴性症状评分低于治疗前,差异有统计学意义(P<0.05)。观察组的阴性症状评分减分值为3.7±1.4,高于对照组的1.5±1.1(P<0.05)。观察组治疗有效率为52.4%,高于对照组的20.0%(P<0.05)。未观察到明显不良反应。结论10 Hz左侧前额叶rTMS联合抗精神病药治疗精神分裂症难治性阴性症状有效。
Objective To explore the therapeutic effects of left dorsolateral prefrontal cortex （DLPFC） repetitive tran- scranial magnetic stimulation （rTMS） for refractory negative symptom of schizophrenic. Methods Forty-one schizophrenia pa- tients with refractory negative symptom were recruited. The patients were randomly divided into observation group （ n = 21 ） which was treated with 10 Hz rTMS at DLPFC for twenty times, and control group （n = 20） which was treated with false rTMS. The type and dose of original antipsychotie drugs were unchanged during treatment period. Clinical symptom was measured with the positive and negative symptom scale （PANSS）. Side effects were evaluated with the treatment emergent symptom scale （TESS）. Results The negative symptoms scores after treatment of observation group were significantly lower than before treatment（ P 〈 0.05 ）. Reduction of negative symptoms score in observation group was 3.7 ±1.4, which was higher than that in control group （ 1.5 ± 1.1 ） （P 〈 0.05 ）. The effective rate of observation group was higher than that of control group（52.4% vs 20.0% ,P 〈 0.05 ）. No obvious side effects of rTMS were observed. Conclusion It may be effective for combination of 10 Hz rTMS and antipsychotics to treat schizophrenia with refractory negative symptom.
出处
《新乡医学院学报》
CAS
2013年第11期895-897,901,共4页
Journal of Xinxiang Medical University
基金
全军医学科研计划(编号:CWS12J071)
关键词
精神分裂症
经颅磁刺激
随机对照研究
schizophrenia
transcranial tagnetic stimulate
randomized controlled trial
