摘要
胃癌(gastric cancer,GC)是严重危害人类健康的恶性肿瘤之一,除与幽门螺杆菌(Helicobacter pylori,H.pylori)感染有密切关系外,部分研究认为白介素-1B(interleukin-1B,IL-1B)基因多态性与GC易感性存在关联,从而增加GC的发生风险.然而,此观点尚存在争议.综述IL-1B基因多态性在不同地区、不同种族间与GC易感性之间关系的研究和进展,为进一步探讨二者关系提供参考.
Gastric cancer is one of severe diseases threaten- ing human health and has a close association with Helicobacter pylori infection. Interleukin-lB （IL-1B） gene polymorphisms have been sug- gested to be associated with susceptibility to gastric cancer; however, there is still controversy over this point of view. In this paper we will summarize recent progress in understanding the association between IL-1B gene polymorphisms and susceptibility to gastric cancer in population in different areas or of different races.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第32期3493-3498,共6页
World Chinese Journal of Digestology
关键词
白介素-1B
基因多态性
胃癌
Interleukin-lB
Gene polymorphism
Gastric cancer
