摘要
目的 探讨Th1/Th2型细胞因子及免疫状态在支气管哮喘患儿治疗前后中的变化.方法 选取榆林市儿童医院2011年5月～2013年3月收治的48例支气管哮喘患儿为研究对象（研究组）,另外选取同期进行健康体检的48例健康儿童作为对照组,检测两组研究对象治疗前及治疗后1、4周时Th1细胞因子[白介素-2（IL-2）、干扰素-γ（IFN-γ）]、Th2细胞因子[白介素-4（IL-4）、白介素-5（IL-5）、白介素-10（IL-10）、白介素-13（IL-13）]和免疫指标,并进行统计学比较.结果 治疗前研究组患儿IL-2 、IFN-γ和IL-10均明显低于对照组（t=8.52、11.84、6.57）,IL-4、IL-5和IL-13明显高于对照组（t=12.98、15.87、11.88）,差异均有统计学意义（P＜0.05）.治疗1、4周后研究组患儿Th1/Th2型细胞因子均明显改善,治疗4周时Th1/Th2型细胞因子水平与对照组比较,差异无统计学意义（P＞0.05）.治疗前研究组患儿CD3＋、CD4＋及CD4/CD8均明显低于对照组（t=9.23、10.52、8.11）,而CD8＋则高于对照组（t=9.61）,差异有统计学意义（P＜0.05）.治疗1、4周后研究组患儿各项免疫指标均明显改善,治疗4周时CD3＋、CD4＋、CD8＋及CD4/CD8水平与对照组比较,差异无统计学意义（P＞0.05）.研究组各时间段Th1、Th2细胞因子比较,差异有统计学意义（F=1.96、3.19、3.25、4.01、2.15、1.81,均P＜0.05）.研究组各时间段各免疫指标比较,差异有统计学意义（F=3.74、2.53、3.06、1.98,均P＜ 0.05）.结论 支气管哮喘患儿治疗前后Th1/Th2型细胞因子及免疫状态存在显著变化.
Objective To explore the changes of Th1/Th2 type cytokines and immune status in children with bronchial asthma before and after treatment.Methods 48 cases of children with bronchial asthma who were treated in c Children＇s Hospital of Yulin City from May 2011 to March 2013 were selected as the research group,in addition,48 healthy children who were given health physical examination were selected as the control group,the Th1 cytokines [including interleukin-2 （IL-2） and gamma interferon-γ（IFN-gamma）],the Th2 cytokine [including interleukin-4 （IL-4） and interleukin-5 （IL-5） and interleukin-10 （IL-10） and interleukin-13 （IL-13）] and immune indexes in both groups before and after 1,4 weeks treatment were detected and statistical compared.Results The IL-2,IFN-γand IL-10 in research group before treatment were lower than those in control group （t =8.52,11.84,6.57）,and IL-4,IL-5 and IL-13 in research group before treatment were higher than those in control group （t =12.98,15.87,11.88）,the differences were statistically significant （P ＜ 0.05）.The Th1/Th2 type cytokines in research group of 1,4 weeks after treatment were significantly improved,the differences of Th1/Th2 type cytokines level between research group 4 weeks after the treatment and control group was not statistically significant （P ＞ 0.05）.The CD3＋,CD4＋ and CD4/CD8 in research group before treatment were lower than those in control group （t =9.23,10.52,8.11）,while CD8＋ in research group before treatment was higher than that in control group （t =9.61）,the differences were statistically significant （P ＜ 0.05）.The various immune indexes after treatment 1,4 weeks were significantly improved,the differences of CD3＋,CD4＋,CD8＋ and CD4/CD8 level between research group 4 weeks after the treatment and control group was not statistically significant （P ＞ 0.05）.The differences of Th 1,Th2 cytokines in each time period of the research group were statistically significant （F =1.96,3.19,3.25,4.01,2.15,1.81,P ＜ 0.05）.The differences of immune index in each time in the research group were statistically significant （F =3.74,2.53,3.06,1.98,P ＜ 0.05）.Conclusion The children with bronchial asthma before and after treatment of Th1/Th2 type cytokines and immune state have significant changes.
出处
《中国医药导报》
CAS
2013年第33期81-83,共3页
China Medical Herald
