摘要
中药的安全性近年来受到了广泛的关注和重视,但是相应的理论和实验研究还不够充分。中药的毒性是中药安全性的关键问题之一,参照国际惯例和西方植物药研究的标准规范,依据中医药理论,应用现代新技术新方法,结合基础研究的成果,制定相应的评价体系和研究规范,是解决这个关键问题的可行思路。对近年来课题组按照上述研究思路开展的有关中药毒性评价的技术方法与应用研究的结果进行了概述,希望能为中药毒性的评价方法和技术指导原则提供理论基础,也可为雷公藤等典型中毒中药的毒性研究提供研究示范,推动中药毒性研究的发展。
the safety of traditional Chinese medicine （TCM） has gained widespread concern and attention in recent years, the corresponding theoretical and experimental studies have not been sufficient. The toxicity of TCM is one of the kcy problems in safety. To solve this critical problem, we could refer to the international practices, the western botanical medicine researches, the hasis of the theory of TCM, the application of modern technologies and new methods, the results of basic research and the development of appropriate evaluation system and research specification. In this paper, we outlined the outcomes of the recent technical methods and applied research related to the evaluation of the toxicity of TCM to provide theoretical basis for TCM toxicity evaluation and technical guidelines, which could also provide research demonstration for typical toxic TCM, such as Tripterygium wiltbrdii as well as promote the development of TCM toxicity studies.
出处
《药学进展》
CAS
2013年第11期545-554,共10页
Progress in Pharmaceutical Sciences
基金
国家十五科技攻关计划(No.2004BA721A15)
中医药行业科研专项(No.200707008)
国家科技支撑计划(No.2007BAI30B04)
十一五"重大新药创制"科技重大专项(No.2009ZX09302–002)
中央高校基本科研业务费专项基金研究生专项(No.JKY2009058
No.JKY2011034)
国家自然科学基金(No.81173651)
国家自然科学基金重大国际(地区)合作研究项目(No.81320108029)
江苏省自然科学基金(No.BK2011631)
关键词
中药毒性
毒性评价模型
肝毒性
肾毒性
雷公藤
TCM toxicity
toxicity evaluation model
hepatotoxicity
nephrotoxicity
tripterygium wiltbrdii
