摘要
目的探索类风湿性关节炎(rheumatoid arthritis,RA)中医辨证分型的客观基础,研究RA各证型类风湿因子(rheumatoid factor,RF)、抗环瓜氨酸肽(citrullinated protein antibody,CCP)抗体分型差异。方法选择230例早期RA患者,按证型分为湿热痹阻(50例)、寒湿痹阻(50例)、肾气虚寒(50例)、肝肾阴虚(40例)、瘀血痹阻组(40例),另选择体检健康者100名作为健康对照组。比较各组血清类风湿因子——RF-IGM、RF-IGA、RF-IGG、抗CCP抗体。结果湿热痹阻、寒湿痹阻、肾气虚寒、肝肾阴虚、瘀血痹阻组抗CCP抗体及RF-IGM、RF-IGA、RF-IGG浓度均高于健康对照组(P<0.01);各组活动期抗CCP抗体及RFIGM、RF-IGA、RF-IGG高于非活动期(P<0.05);活动期湿热痹阻型抗CCP抗体及RF-IGM、RF-IGA、RF-IGG浓度高于肾气虚寒、肝肾阴虚、瘀血痹阻型(P<0.01)。结论类风湿因子RF-IGM、RF-IGA、RF-IGG、抗CCP抗体浓度可作为RA中医辨证分型的客观实验室指标和活动期的判定指标。
Objective To study the objective diagnostic mechanisms on Chinese medical （CM） syndrome patterns of rheumatoid arthritis （RA）, and to research different titers of rheumatoid factor （RF）/citrullinated protein antibody （CCP） in CM syndrome patterns of RA. Methods Totally 230 early RA patients were assigned to five CM syndrome pattern groups, i.e., the dampness-heat blockage group （50 cases）, the cold-dampness blockage group （50 cases）, the Shen-qi deficiency-cold group （50 ca- ses）, the Gan-Shen yin deficiency group （40 cases）, and the blood stasis blockage group （40 cases）. Another 100 healthy subjects were recruited as the healthy control group. RF-IGM, RF-IGA, RF-IGG, and anti-CCP antibody were detected and compared. Results The titers of RF-IGM, RF-IGA, RF-IGG, and an- ti-CCP antibody were higher in all groups than in the healthy control groups （P 〈0.01 ）. As for the 5 groups, RF-IGM, RF-IGA,RF-IGG, and anti-CCP antibody were higher in the RA active stage than in the nonactive stage. They were higher in the dampness-heat blockage group in the RA active stage than in the Shen-qi deficiency-cold group, the Gan-shen yin deficiency group, and the blood stasis blockage group. Conclusion Titers of RF-IGM, RF-IGA,RF-IGG, and anti-CCP antibody could be taken as judging indicators for differentiating objective lab indices of CM syndromes and assessing the active stage of RA.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2013年第12期1608-1610,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
上海市自然科学基金资助项目(No.11ZR1427000)
上海市长宁区卫生局科研课题(No.2012012)
