摘要
难治性胃食管反流病目前已成为临床上的棘手问题。其发生机制尚未完全阐明。上消化道内镜、食管内动态pH监测以及食管多通道腔内阻抗-pH值监测等技术能够对难治性胃食管反流病的诊断提供帮助。通过改善患者的服药依从性以及调整质子泵抑制剂的剂量、种类和服药时间,配合促胃肠动力药、一过性下食管括约肌松弛抑制剂、疼痛调节剂或抗反流手术均有助于改善患者的顽固症状。
Refractory gastroesophageal reflux disease （GERD）has become a troublesome problem in clinical practice. Its pathogenesis has not been fully elucidated. Upper gastrointestinal endoscopy, esophageal dynamic pH monitoring and esophageal muhi-channel cavity impedance-pH monitoring can offer help for the diagnosis of refractory GERD. Measures such as improving the compliance of the patients, adjustment of the dose, species and taking medicine time of proton pump inhibitor （PPI）, combination therapy with prokinetic agents, transient lower oesophageal sphincter relaxation （TLESR）inhibitors, visceral pain modulators or anti reflux operation can contribute to the improvement the persistent symptoms of patients with refractory GERD.
出处
《中华消化病与影像杂志（电子版）》
2013年第5期1-4,共4页
Chinese Journal of Digestion and Medical Imageology(Electronic Edition)
关键词
胃食管反流
质子泵抑制剂
食管PH监测
上消化道内镜
Gastroesophageal reflux
Proton pump inhibitors
Esophageal pH monitoring
Upper gastrointestinal endoscopy
