摘要
目的 :研究P16和细胞周期蛋白D1在子宫内膜癌中的表达及其临床意义。方法 :采用免疫组化LSAB法检测 42例子宫内膜癌中P16、细胞周期素D1的表达。结果 :42例子宫内膜癌中 2 0例p16表达阳性 ,占 47 6 % ,p16与子宫内膜癌的细胞分级、临床分期、肌层浸润深度有关 (P <0 0 5 ) ;17例子宫内膜癌细胞周期素D1表达阳性 ,占 40 4% ,细胞周期素D1与子宫内膜癌的细胞分级、临床分期、淋巴结转移有关 (P <0 0 5 ) ;p16、细胞周期素D1协同表达 15例 ,均为晚期或低分化癌。结论 :p16、细胞周期素D1作为细胞周期调节因子参与子宫内膜癌的发生、发展 ,其协同作用促进子宫内膜癌的发展。
Purpose:To investigate the expression of P16 and cyclinD1 in endometrial carcinoma and their clinical significance. Methods:42 cases of endometrial carcinoma were studied by immunohistochemical technique.Results:In 42 cases of endometrial carcinoma, the positive rate of p16 experssion was 47.6% (20/42), P16 was significantly associated with pathological grade, clinical stage, myometrial invasions ( P <0 05); The positive rate of cyclin D1 expression was 40.4% (17/42),cyclin D1 was significantly associated with pathological grade, clinical stage, metastases ( P <0 05); 15 cases of endometrial carcinoma was co expressed, which were late stages cancer.[WT5”,6HZ]Conclusions:p16 and cyclin D1 as cell cycle regulatory factors may be invoved in the development of endometrial carcinoma and these synergistic effects of p16 and cyclin D1 would lead to.
出处
《中国癌症杂志》
CAS
CSCD
2000年第6期502-503,506,共3页
China Oncology
